Glycobiology of the Nervous System

Cara-Lynne Schengrund, PhD, is Professor Emeritus, Department of Biochemistry and Molecular Biology, Penn State University, Hershey, PennsylvaniaRobert K. Yu, PhD, Med ScD, was Professor, Department of Neuroscience and Regenerative Medicine, and GRA Eminent Scholar in Molecular and Cellular Neurobiology, Medical College of Georgia at Augusta University, Augusta, Georgia

• 1. Introduction to the complexity of cell surface and tissue matrix glycoconjugates..- 2. Introduction to cells comprising the nervous system..- 3. Synthesis.- processing.- and function of N-glycans in N-glycoproteins..- 4. Synthesis of O-linked glycoconjugates in the nervous system..- 5.  Chemistry and function of glycosaminoglycans in the nervous system..- 6.  Use of glycan-targeted antibodies/lectins to study the expression/function of glycosyltransferases in the nervous system..- 7.  Capillary electrophoresis and mass spectrometry-based glycosylation analysis in glycomics and glycoproteomics..- 8.  Structural analysis of oligosaccharides and glycoconjugates using NMR..- 9.  Glycolipid and glycoprotein expression during neural development..- 10. Gangliosides and cell surface ganglioside glycohydrolases in the nervous system (request them to include gal-cer and sulfatide)..- 11. Role of myelin-associated glycoproteins in the peripheral nervous system..- 12. Glycosignaling: a general review..- 13. Glycosphingolipids in the regulation of the nervous system..- 14. O-GlcNAcylation of neuronal proteins: Roles in neuronal functions and in neurodegeneration..- 15.  Glycoconjugates in nuclear membranes..- 16. N-glycosylation in regulation of the nervous system..- 17. Role of carbohydrates in the interaction of pathogens with neural cells..- 18. Glycoconjugate changes in aging and age-related diseases..- 19. Gangliosides and glycolipids in neurodegenerative disorders..- 20. Inborn errors of glycosphingolipid catabolism and potential treatment..- 21. Neurological aspects of human glycosylation disorders..- 22. Glycoconjugates and neural tumors..- 23. Galectins and neuroinflammation ..- 24. Glycoconjugates and neuroimmunological diseases..- 25. Targeting nanoparticle drug carriers to the brain..- 26. Use of quantum dots to treat inherited lysosomal storage diseases..- 27.  MALDI-FTICR MS imaging of nervous system glycoconjugates.