Glutamate-based Therapies for Psychiatric Disorders

• N-Methyl-d-Aspartate (NMDA) Antagonists for the Treatment of Depression.- Ionic Glutamate Modulators in Depression (Zinc, Magnesium).- Positive Allosteric Modulation of AMPA Receptors: A Novel Potential Antidepressant Therapy.- Glutamatergic Modulators for the Treatment of Major Depressive Disorder: Metabotropic Glutamate Receptors.- Positive Modulation of AMPA Receptors as a Broad-Spectrum Strategy for Treating Neuropsychiatric Disorders.- Activation of Group II Metabotropic Glutamate Receptors (mGluR2 and mGluR3) as a Novel Approach for Treatment of Schizophrenia.- mGluR1 Negative Allosteric Modulators: An Alternative Metabotropic Approach for the Treatment of Schizophrenia.- Metabotropic Glutamate Receptors as Targets for the Treatment of Drug and Alcohol Dependence.- Metabotropic Approaches to Anxiety.

From the reviews:“This book summarizes the translational research in the development of glutamate-based approaches to treat psychiatric disorders. Written and edited by an international group of researchers, it is an important addition to the psychiatric literature. … The intended audience includes psychiatric researchers and psychiatrists. Neuroscientists interested in the treatment of patients with psychiatric disorders also would benefit from reading this book. … The index is quite helpful. … presents a unique and novel approach that is desperately needed in the treatment of these difficult disorders.” (Michael Joel Schrift, Doody’s Review Service, February, 2011)