Glial Physiology and Pathophysiology

Häftad, Engelska, 2013

1 219 kr

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Glial Physiology and Pathophysiology provides a comprehensive, advanced text on the biology and pathology of glial cells.Coverae includes: the morphology and interrelationships between glial cells and neurones in different parts of the nervous systemsthe cellular physiology of the different kinds of glial cellsthe mechanisms of intra- and inter-cellular signalling in glial networksthe mechanisms of glial-neuronal communicationsthe role of glial cells in synaptic plasticity, neuronal survival and development of nervous systemthe cellular and molecular mechanisms of metabolic neuronal-glial interactionsthe role of glia in nervous system pathology, including pathology of glial cells and associated diseases - for example, multiple sclerosis, Alzheimer's, Alexander disease and Parkinson'sNeuroglia oversee the birth and development of neurones, the establishment of interneuronal connections (the 'connectome'), the maintenance and removal of these inter-neuronal connections, writing of the nervous system components, adult neurogenesis, the energetics of nervous tissue, metabolism of neurotransmitters, regulation of ion composition of the interstitial space and many, many more homeostatic functions. This book primes the reader towards the notion that nervous tissue is not divided into more important and less important cells. The nervous tissue functions because of the coherent and concerted action of many different cell types, each contributing to an ultimate output. This reaches its zenith in humans, with the creation of thoughts, underlying acquisition of knowledge, its analysis and synthesis, and contemplating the Universe and our place in it. An up-to-date and fully referenced text on the most numerous cells in the human brainDetailed coverage of the morphology and interrelationships between glial cells and neurones in different parts of the nervous systemDescribes the role og glial cells in neuropathologyFocus boxes highlight key points and summarise important factsCompanion website with downloadable figures and slides

Produktinformation

Utgivningsdatum2013-03-22
Mått170 x 246 x 28 mm
Vikt871 g
FormatHäftad
SpråkEngelska
Antal sidor560
FörlagJohn Wiley and Sons Ltd
ISBN9780470978535

Tillhör följande kategorier

Biovetenskap inom Naturvetenskap och teknik

Preface xviiAbout the Authors xxiAbbreviations xxvAbout the Companion Website xxxii1 History of Neuroscience and the Dawn of Research in Neuroglia 11.1 The miraculous human brain: localising the brain functions 11.2 Cellular organisation of the brain 101.3 Mechanisms of communications in neural networks 141.4 The concept of neuroglia 271.5 Beginning of the modern era 471.6 Concluding remarks 49References 492 General Overview of Signalling in the Nervous System 592.1 Intercellular signalling: wiring and volume modes of transmission 592.2 Cellular signalling: receptors 622.3 Intracellular signalling: second messengers 672.4 Calcium signalling 672.5 Concluding remarks 723 Neuroglia: Definition, Classification, Evolution, Numbers, Development 733.1 Definition of neuroglia as homeostatic cells of the nervous system 743.2 Classification 753.3 Evolution of neuroglia 763.4 Numbers: how many glial cells are in the brain? 933.5 Embryogenesis and development of neuroglia in mammals 963.6 Concluding remarks 99References 1004 Astroglia 1054.1 Definition and heterogeneity 1074.2 Morphology of the main types of astroglia 1134.3 How to identify astrocytes in the nervous tissue 1194.4 Astroglial syncytial networks 1204.5 Physiology of astroglia 1254.6 Functions of astroglia 1754.7 Concluding remarks 231References 2315 Oligodendrocytes 2455.1 Oligodendrocyte anatomy 2475.2 Myelin structure and function 2525.3 Physiology of oligodendrocytes 2665.4 Oligodendrocyte development 2835.5 Concluding remarks 299References 2996 NG2-glial Cells 3216.1 Definition of NG2-glia 3216.2 Structure of NG2-glia 3246.3 Physiology of NG2-glia 3276.4 Proliferation of NG2-glia and generation of oligodendrocytes 3326.5 Relationship between NG2-glia and CNS pericytes 3336.6 Evolution of NG2-glia 3366.7 Concluding remarks 337References 3377 Microglia 3437.1 Definition of microglia 3447.2 Microglial origin and development 3457.3 Morphology of microglia 3457.4 General physiology of microglia 3517.5 Microglial migration and motility 3727.6 Physiological functions of microglia: role in synaptic transmission and plasticity 3737.7 Microglia in ageing 3757.8 Concluding remarks 375References 3768 Peripheral Glial Cells 3818.1 Peripheral nervous system 3828.2 Schwann cells 3908.3 Satellite glial cells 4078.4 Enteric glia 4128.5 Olfactory ensheathing cells (OECs) 4188.6 Concluding remarks 422References 4239 General Pathophysiology of Neuroglia 4319.1 Neurological disorders as gliopathologies 4319.2 Reactive astrogliosis 4339.3 Wallerian degeneration 4399.4 Excitotoxic vulnerability of oligodendrocytes: the death of white matter 4429.5 Activation of microglia 4449.6 Concluding remarks 449References 45010 Neuroglia in Neurological Diseases 45310.1 Introduction 45410.2 Genetic astrogliopathology: Alexander disease 45610.3 Stroke and ischaemia 45810.4 Migraine and spreading depression 46710.5 CNS oedema 46910.6 Metabolic disorders 47110.7 Toxic encephalopathies 47310.8 Neurodegenerative diseases 47410.9 Leukodystrophies 48710.10 Epilepsy 48810.11 Psychiatric diseases 49010.12 Autistic disorders 49110.13 Neuropathic pain 49210.14 Demyelinating diseases 49410.15 Infectious diseases 49610.16 Peripheral neuropathies 49910.17 Gliomas 50110.18 Concluding remarks 504References 504Author Index 513Subject Index 517

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