Nicholas J. Talley, University of Newcastle, Callaghan, NSW, AustraliaG. Richard Locke III, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine,Rochester, MN, USAPaul Moayyedi, McMaster University, Hamilton, ON, CanadaJoe West, Leeds Teaching Hospital Trust, University of Nottingham, Nottingham, UKAlexander C. Ford, Leeds General Infirmary, Leeds, UKYuri A. Saito, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN, USA