Genome Damage

Nyhet

Repair and Adaptation Across Life

Häftad, Engelska, 2026

Av Vinod Kumar Kannaujiya, Ganesh K. Maurya, Rajesh P. Rastogi, Ganesh K Maurya, Rajesh P Rastogi

2 469 kr

Kommande

Genome Damage: Repair and Adaptation across Life explores the significance of nucleic acid damage from environmental pollutants, UV radiation and other stressors, which can lead to mutations, genetic instability, and various diseases, including cancer. This book delves into the mechanisms of DNA and RNA repair, which are crucial for maintaining cellular health and enabling evolutionary adaptations. The book examines these intricate processes across microbes, plants, and animals, providing a comprehensive understanding of how genetic materials are regulated and repaired under diverse environmental conditions. It covers a wide range of topics, including advanced molecular mechanisms of nucleotide repair, UV-induced damage, apoptosis cell death and autophagy, genetic instability in crops, and the role of post-translational modifications in DNA repair. The text also explores the detection and quantification of DNA damage, the impact of synthetic chemicals and climate change on nucleic acids, and the therapeutic significance of DNA repair mechanisms. The book closes with a look towards future perspectives. Genome Damage: Repair and Adaptation across Life is an invaluable resource for students, researchers, and professionals in molecular biology, cytogenetics, genomics, microbiology, ecotoxicology, plant biotechnology and the pharmaceutical industry. It is particularly beneficial for those studying the molecular mechanisms of DNA damage from an evolutionary perspective and those developing therapeutic strategies for cancer, oxidative diseases, and aging-related disorders.

Covers nucleic acid damage and repair mechanisms across a range of organisms
Provides insights into environmental adaptability and evolutionary significance of genetic mutations
Discusses detection and prevention strategies for DNA damage
Offers therapeutic applications for genetic disorders, including cancer and aging-related diseases

Produktinformation

Utgivningsdatum2026-06-01
Mått191 x 235 x undefined mm
Vikt450 g
FormatHäftad
SpråkEngelska
Antal sidor450
FörlagElsevier Science
ISBN9780443428579

Tillhör följande kategorier

Biologi inom Naturvetenskap och teknik

Dr. Vinod Kumar Kannaujiya is an assistant professor in the Department of Botany, MMV, Banaras Hindu University, India. He earned his MSc and PhD degrees in Botany from the Centre of Advanced Study in Botany, Banaras Hindu University. He has been working on the ultraviolet stress response of cyanobacteria including value-added enzymes, proteins, pigments, and natural compounds. He has been awarded with prestigious fellowships from the Council of Scientific and Industrial Research, New Delhi, India. He has also been awarded the Dr. D.S. Kothari Post-Doctoral Fellowship from University Grant Commission, New Delhi, India, and he has received a UGC-Startup project grant from UGC, New Delhi, India. Dr. Kannaujiya is a life member fellow of the Indian Photobiology Society. Thus far, Dr. Kannaujiya has published over 49 original research papers, reviews, and book chapters. Dr. Ganesh Kumar Maurya is an assistant professor in the Department of Zoology, MMV, Banaras Hindu University, Varanasi, India. He received his M.Sc. degree in Zoology from the Centre of Advanced Study in Zoology, Banaras Hindu University, Varanasi, India and Ph.D. in Life Science from Bhabha Atomic Research Centre, HBNI, Mumbai, India. He has been working on genome maintenance under oxidative stress including Gamma radiation in the polyextremophile Deinococcus radiodurans. Beside this, he is also working on the antibiotic resistance and phage therapy against the pathogenic bacteria. He has received gold medals in M.Sc. and Ph.D. He is the recipient of a prestigious ‘Young Scientist Award from National Academy of Sciences, India’. He is also the recipient of UGC-Startup, SRG-SERB, IoE project grant from various funding agencies. He is a life member fellow of the Society of Biological Chemist (India). He has published over 25 original research papers, reviews, and book chapters. Dr. Rajesh P Rastogi is currently working as a Scientist/Joint Director at the Ministry of Environment, Forest and Climate Change, New Delhi, India. He completed his Ph. D. on UV-induced DNA Damage and Repair at Banaras Hindu University, Varanasi, India. Dr. Rastogi is the recipient of some national and international awards and fellowships. He was a visiting scientist at Friedrich Alexander University, Nuremberg, Germany and served as a visiting professor of biochemistry at Chulalongkorn University, Thailand. His major research areas are freshwater or marine algae and cyanobacterial ecology and biotechnology, plant physiology, photochemistry, photobiology, molecular microbiology and stress biology. Dr. Rastogi has already published more than 100 referred international peer reviewed research papers, review articles in high impact journals of international repute. He has also published several book chapters and five books from renowned international publishers (Elsevier/Springer/Nova). He is serving as an editorial board member of some national and international journals and is life member of several scientific organizations.

1. Genome research: basic concept and recent advances2. Nucleotide repair mechanism: fundamental to molecular advances3. Nucleotide damage and its role in the evolution of microbes4. UV mediated damage and repair in bacterial communities5. Oxidative stress and nucleotide mutagenesis in microbes6. DNA Photolyase: Properties and mode of action7. DNA repair in extremophiles8. Genetic instability in crop plants: evolution and modern perspectives9. UV-induced DNA damage and repair in higher plants10. Ionizing radiation induced mammalian cell damage and repairs11. Non ionizing radiation induced DNA damage and repair in animals12. Oxidative DNA damage: repair mechanisms and associated disorder in humans13. Responses of cell checkpoint on DNA mutagenesis14. DNA damage and autophagy: mechanisms and significance15. Role of Post translational modification in DNA repair16. Detection of DNA damage and repair: a technological development17. Cellular quantification of DNA damage and its repair18. Eco-toxicity of synthetic chemicals and DNA health19. Effects of climate change on nucleic acid composition20. RNA damage and repair mechanism21. DNA damage and cancer: advances, risk assessment and opportunities22. Metal stress and DNA mutagenesis23. Recent development in photonic induced photorepair mechanism24. Apoptosis cell death and DNA damage25. Significance of plant nutraceuticals in DNA repair26. Significance of algal green chemicals in repair mechanism27. DNA damage and repair: a disease specific therapeutic significance28. DNA damage and aging: Concept, feasibility, and significance29. SOS response and molecular check point repair30. DNA damage and recombination repair during DNA replication31. Structural and dynamical signatures of DNA damage32. Impacts of nanoparticles on DNA damage and repair33. Bioprospecting of active metabolites for repair of DNA damage34. DNA photosensitization-application and future perspectives35. DNA damage and repair: Future perspectives