Kropp & själ
Genetic Effects on Environmental Vulnerability to Disease
Sir Michael J Rutter
Inbunden
1789:-
Uppskattad leveranstid 11-21 arbetsdagar
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Much research has attempted to show direct linear relations between genes and disorder. However, scientists have been discouraged by inconsistent findings based on this simple gene-phenotype approach. The alternative approach is to incorporate information about the environment. A gene-environment interaction approach assumes that environmental pathogens cause disorder, whereas genes influence susceptibility to environmental pathogens. This book brings together contributions from experts from multiple disciplines who discuss: How epidemiological cohort studies can better integrate physiological (mechanistic) measures; How best to characterise subjects' vulnerability versus resilience by moving beyond single genetic polymorphisms; How gene hunters can benefit from recruiting samples selected for known exposures; How environmental pathogens can be used as tools for gene hunting; How to deal with potential spurious (statistical) interactions, and How genes can help explain fundamental demographic properties of disorders (e.g. sex distribution, age effects).
- Format: Inbunden
- ISBN: 9780470777800
- Språk: Engelska
- Antal sidor: 232
- Utgivningsdatum: 2008-06-01
- Förlag: John Wiley & Sons Inc