Gene-Environment Interactions

Lucio G. Costa, Ph.D., is professor of environmental health and toxicology at the University of Washington School of Public Health and Community Medicine. He is also director of the NIEHS-sponsored Neurotoxicology Research Core at the Center in Ecogenetics and Environmental Health. His research is focused on the study of the cellular, biochemical and molecular mechanisms involved in neurotoxicity using biochemical, molecular and imaging techniques. David L. Eaton is Professor of Environmental Health and Associate Dean for Research in the School of Public Health and Community Medicine at the University of Washington. He serves as Director of the Center for Ecogenetics and Environmental Health, and is also Deputy Director for a major NIEHS-sponsored research initiative in the area of toxicogenomics. Dr. Eaton's research interests focus on understanding how subtle genetic differences between individuals and species can result in potentially large differences in susceptibility to chemical carcinogens.

• Foreword. Acknowledgments.Contributors.PART I.Chapter 1. Introduction (Lucio G. Costa and David L. Eaton).Chapter 2. Ecogenetics: Historical Perspectives (Gilbert S. Omenn and Arno G. Motulsky).Chapter 3. Tools of Ecogenetics (Theo K. Bammler, Federico M. Farin, and Richard P. Beyer).Chapter 4. Epidemiologic Approaches (Harvey Checkoway, Parveen Bhatti, and Anneclaire De Roos).Chapter 5. Statistical Issues in Ecogenetic Studies (Stephanie A. Monks).PART II.Chapter 6. Overview of Section II (Lucio G. Costa and David L. Eaton).Chapter 7. Polymorphisms in Cytochrome P450 and Flavin-Containing Monooxygenase Genes (Catherine K.Yeung, Allan E. Rettie, and Kenneth E. Thummel)Chapter 8. Polymorphisms in Xenobiotic Conjugation (Helen E. Smith, David L. Eaton, and Theo K. Bammler).Chapter 9. Paraoxonase, Butyrylcholinesterase, and Epoxide Hydrolase (Lucio G. Costa, Toby B. Cole, Gary K. Geiss, and Clement E. Furlong).Chapter 10. DNA Repair Enzymes (Jon P. Anderson and Lawrence A. Loeb).Chapter 11. Receptors and Ion Channels (Lucio G. Costa).PART III.Chapter 12. Overview of Section III (Lucio G. Costa and David L. Eaton).Chapter 13. Lung Cancer (Valle Nazar-Stewart).Chapter 14. Gastrointestinal Cancers (Thomas L.Vaughan).Chapter 15. Neurodegenerative Diseases (Samir N. Kelada, Harvey Checkoway, and Lucio G. Costa).Chapter 16. Cardiovascular Disease (Melissa A.Austin and Stephen M. Schwartz).Chapter 17. Type 2 Diabetes (Karen L. Edwards).Chapter 18. Infectious Disease Ecogenetics (David R. Sherman).Chapter 19. Genetic Variation, Diet, and Disease Susceptibility (Johanna W. Lampe and John D. Potter).Chapter 20. Genetic Determinants of Addiction to Alcohol, Tobacco, and Drugs of Abuse (Andrew J. Saxon).PART IV.Chapter 21. Overview of Section IV (Lucio G. Costa and David L. Eaton).Chapter 22. Ethical Issues in Ecogenetics (Kelly Fryer-Edwards, Lindsay A. Hampson, Christopher R. Carlsten, and Wylie Burke).Chapter 23. Social and Psychological Aspects of Ecogenetics (Deborah Bowen, Shirley Beresford, and Brenda Diergaarde).Chapter 24. Legal Issues (Kate Battuello and Anna Mastroianni).Chapter 25. Risk Assessment and the Impact of Ecogenetics (Elaine M. Faustman and Gilbert S. Omenn).Bibliography.Index.

"…highly recommended for academic libraries that have undergraduate and graduate studies in genetics, toxicology, and pharmacology." (E-STREAMS, September 2007) "...a great accomplishment, and it can well serve as a primary, extensively-referenced text..." (American Journal of Medical Genetics, Part A, August 1, 2007)"...a must-have for all toxicology and pharmacology students as well as a great resource for researchers and physicians." (Environmental Health Perspectives, June 2006)"...a vital in-office reference for any scientific researcher dedicated to the study of genetics...invaluable to public health researchers who are look at how global threats live Avian Flu might spread to the general populous...an indispensable reference to all health science libraries." (The Electric Review, March/April 2006)