Gene Engineering in Endocrinology

• I Growth, Development, and Metabolism.- 1 Differential Cell Signaling and Gene Activation by the Human Growth Hormone Receptor: From Cell Surface to Cell Nucleus.- 2 Insulin Action: Molecular Mechanisms and Determinants of Specificity.- 3 Ets Transcription Factors: Nuclear Integrators of Signaling Pathways Regulating Endocrine Gene Expression and Carcinogenesis.- 4 Pit-1 Expression, Regulation, and Modulation of Multiple Pituitary Genes.- 5 Subnuclear Trafficking of Glucocorticoid Receptors: General Mechanisms and Specific Recruitment to a Unique Target Site by Tethering to a DNA-Bound POU Domain Protein.- 6 Thyroid Hormone Receptors and Their Multiple Transcriptional Roles.- 7 Models of Resistance to Thyroid Hormone.- 8 Thyroid Hormone Receptor Family Members: Homodimers, Heterodimers, and Mechanisms of Transcriptional Repression.- 9 SF-1 and DAX-1: A Dynamic Duo in Endocrine Development.- II Reproductive System.- 10 Gene Knockout Models to Study the Hypothalamus-Pituitary-Gonadal Axis.- 11 Transgenic Approaches to Study Developmental Expression and Regulation of the Gonadotropin Genes.- 12 Molecular Events Defining Follicular Developments and Steroidogenesis in the Ovary.- 13 Regulation of Inhibin Subunit Gene Expression by Gonadotropins and cAMP in Ovarian Granulosa Cells.- 14 Placental Trophoblast Cells: Transcriptional Regulation and Differentiation.- 15 Alternative Splicing of mRNAs for cAMP-Responsive Transcriptional Factors and Modulation of Gene Transcription in the Testis.- 16 The Androgen Receptor, Androgen Insensitivity, and Prostate Cancer.- 17 Genetic Determination of Androgen Responsiveness.- 18 Steroid Receptor Regulation by Phosphorylation and Cell Signaling Pathways.- 19 Steroid Receptor Actions: Agonists and Antagonists and the Role of Coactivators and Corepressors.

"The editor should be congratulated on bringing together some of the most respected researchers in this area to write state-of-the-art papers in the area of molecular endocrinology... Graduate students and fellows interested in basic endocrinology would find this book a worthwhile investment with good diagrams and well-written summaries of some of the more confusing areas of this field...I love the book and will keep it handy when I sit down and decipher the new papers in molecular biology."-Doody's Health Science Book Review Journal