Gastrointestinal Physiology

Leonard R. Johnson received a Ph.D. in physiology from the University of Michigan and then trained with Dr. Morton I. Grossman at UCLA. He spent 17 years as a Professor of Physiology at the University of Texas Medical School in Houston before moving to the University of Tennessee Health Science Center as the Thomas A. Gerwin Professor and Chairman of the Department of Physiology. He is the author or coauthor of over 250 papers on gastrointestinal physiology and holds an NIH MERIT Award. Currently he is the Vice Chancellor for Research at Tennessee.

• Chapter?1 Regulation: Peptides of the Gastrointestinal TractObjectivesGeneral CharacteristicsDiscoveryChemistryDistribution and ReleaseActions and InteractionsCandidate HormonesNeurocrinesParacrinesClinical ApplicationsClinical TestsSummaryKey Words and ConceptsChapter?2 Regulation: Nerves and Smooth Muscle ObjectivesAnatomy of the Autonomic Nervous SystemNeurohumoral Regulation of Gastrointestinal FunctionAnatomy of the Smooth Muscle CellSmooth Muscle ContractionSummaryKey Words and ConceptsChapter?3 SwallowingObjectivesChewingPharyngeal PhaseEsophageal PeristalsisReceptive Relaxation of the StomachClinical ApplicationsClinical TestsSummaryKey Words and ConceptsChapter?4 Gastric Emptying ObjectivesAnatomic ConsiderationsContractions of the Orad Region of the StomachContractions of the Caudad Region of the StomachContractions of the GastroduodenalJunctionContractions of the Proximal DuodenumRegulation of Gastric EmptyingClinical ApplicationsClinical TestsSummaryKey Words and ConceptsChapter?5 Motility of the Small Intestine ObjectivesAnatomic ConsiderationsTypes of ContractionsPatterns of ContractionsVomitingClinical ApplicationsClinical TestsSummaryKey Words and ConceptsChapter?6 Motility of the Large IntestineObjectivesAnatomic ConsiderationsContractions of the Cecum and Ascending ColonContractions of the Descending and Sigmoid ColonMotility of the Rectum and Anal CanalControl of MotilityClinical SignificanceClinical TestsSummaryKey Words and ConceptsChapter?7 Salivary SecretionObjectivesFunctions of SalivaAnatomy and Innervation of the Salivary GlandsComposition of SalivaRegulation of Salivary SecretionClinical CorrelationSummaryKey Words and ConceptsChapter?8 Gastric SecretionObjectivesFunctional AnatomySecretion of AcidOrigin of the Electrical Potential DifferenceElectrolytes of Gastric JuiceStimulants of Acid SecretionStimulation of Acid SecretionInhibition of Acid SecretionPepsinMucusIntrinsic FactorGrowth of the MucosaClinical ApplicationsSummaryKey Words and ConceptsChapter?9 Pancreatic SecretionObjectivesFunctional AnatomyMechanisms of Fluid and Electrolyte SecretionMechanisms of Enzyme SecretionRegulation of SecretionCellular Basis for PotentiationResponse to a MealClinical ApplicationsSummaryKey Words and ConceptsChapter?10 Bile Secretion and Gallbladder FunctionObjectivesOverview of the Biliary SystemConstituents of BileBile SecretionGallbladder FunctionExpulsion of BileClinical ApplicationsClinical TestsSummaryKey Words and ConceptsChapter?11 Digestion and Absorption OF?NUTRIENTSObjectivesStructural-Functional AssociationsDigestionAbsorptionAdaptation of Digestive and Absorptive ProcessesCarbohydrate AssimilationProtein AssimilationLipid AssimilationVitaminsSummaryKey Words and ConceptsChapter?12 Fluid and Electrolyte AbsorptionObjectivesBidirectional Fluid FluXIonic Content of Luminal FluidTransport Routes and ProcessesMechanism for Water Absorption and SecretionIntestinal SecretionClinical ApplicationsCalcium AbsorptionIron AbsorptionSummaryKey Words and ConceptsChapter?13 Regulation of Food IntakeObjectivesAppetite ControlThe Nervous SystemThe Endocrine SystemThe Gastrointestinal SystemClinical ApplicationsSummaryKey Words and ConceptsAppendix A Answer to Self-Study ProblemsAppendix B Comprehensive Multiple-Choice Review ExaminationIndex