Galectins

Anatole A. Klyosov, PhD, is Chief Scientist and cofounder of Pro-Pharmaceuticals, Inc. He has published more than 290 peer-reviewed articles in scientific journals; authored and edited books on enzymes, carbohydrates, and biotechnology, including Wood-Plastic Composites (Wiley); and holds thirty-nine patents.Zbigniew J. Witczak, PhD, has extensive industrial and academic experience in carbohydrates. He has published more than ninety research papers and holds six patents in the fields of carbohydrate, medicinal, and biological chemistry. In 2000, Dr. Witczak was awarded the Melville L. Wolfrom Award of the ACS Division of Carbohydrate Chemistry for his outstanding research contribution to carbohydrate chemistry and service to the division.David Platt, PhD, is Chief Executive Officer and cofounder of Pro-Pharmaceuticals, Inc. He has published peer-reviewed articles and holds many patents, primarily in the field of carbohydrate chemistry. Dr. Klyosov, Dr. Witczak, and Dr. Platt coedited the ACS symposium book Carbohydrate Drug Design.

• Preface viiContributors ix1 Stumbling on Galectins 1Samuel H. Barondes2 Galectins and Their Functions in Plain Language 9Anatole A. Klyosov3 Understanding Galectin Structure–Function Relationships to Design Effective Antagonists 33Irina V. Nesmelova, Ruud P.M. Dings, and Kevin H. Mayo4 Galectins as Regulators of Tumor Growth and Invasion by Targeting Distinct Cell Surface Glycans and Implications for Drug Design 71Hans-Joachim Gabius and Albert M. Wu5 Nuclear and Cytoplasmic Localization of Galectin-1 and Galectin-3 and Their Roles in Pre-mRNA Splicing 87John L. Wang, Kevin C. Haudek, Patricia G. Voss, and Ronald J. Patterson6 Galectins in Regulation of Inflammation and Immunity 97Fu-Tong Liu, Daniel K. Hsu, Ri-Yao Yang, Huan-Yuan Chen, and Jun Saegusa7 Galectins as Danger Signals in Host–Pathogen and Host–Tumor Interactions: New Members of the Growing Group of "Alarmins"? 115Sachiko Sato and Gabriel A. Rabinovich8 The Role of Galectins in Organ Fibrosis 147Neil C. Henderson and Tariq Sethi9 Galectin-1, Cancer Cell Migration, Angiogenesis, and Chemoresistance 157Florence Lefranc, Marie Le Mercier, Ve´ronique Mathieu, and Robert Kiss10 Galectin-3 in the Progression and Metastasis of Colorectal Neoplasia 193James C. Byrd and Robert S. Bresalier11 Galectins in Malignant Gliomas: Expression, Functions, and Possible Therapeutic Options 223Herwig M. Strik and Anna Hoffmann12 Food-Related Carbohydrate Ligands for Galectins 235Valeri V. Mossine, Vladislav V. Glinsky, and Thomas P. MawhinneyIndex 271

"The book is the first galectin book and contains a wealth of information … .The chapters provide researchers with a solid overview of the state of the art in the various subjects and will be useful to many galectin researchers." (ChemBioChem, January 2009) "A comprehensive guide to the current understanding of galectins, their promising potential in drug design." (Forbes, June 2008)