Fundamentals of Medicinal Chemistry

Gareth Thomas is a lecturer at the University of Portsmouth.

• Preface. Acknowledgements.Abbreviations/Acronyms.1. Biological Molecules.2. An Introduction to Drugs and Their Action.3. An Introduction to Drug Discovery.4. The SAR and QSAR Approaches to Drug Design.5. Computer Aided Drug Design.6. Combinatorial Chemistry.7. Selected Examples of Drug Action at some Common Target Areas.8. Pharmacokinetics.9. Drug Metabolism.10. An Introduction to Lead and Analogue Syntheses.11. Drug Development and Production.Appendix 1. Sickle-cell Anaemia.Appendix 2. Bacteria.Appendix 3. Cell Membranes.Appendix 4. Receptors.Appendix 5. Transfer through Membranes.Appendix 6. Regression Analysis.Appendix 7. Enzymes.Answers to Questions.Selected Further Reading.Index.

"... it would be of great value to beginning graduate students in medicinal chemistry... it should be included in any practicing chemist's personal library." (Journal of Medicinal Chemistry, July 29, 2004)"Thomas presents the fundamentals of medicinal chemistry in a clear, concise, and descriptive fashion." (Choice, June 2004, Vol. 41 No. 10)"... provides a concise introduction to the chemistry of therapeutically active compounds, written in a readable and accessible style..." (www.organische-chemie.ch, 19/01/2004)"... well laid out, with an attractive typeface." (Chemistry and Industry, 6th September 2004)