Fundamentals of Brain Organoids for Neurological Diseases

Häftad, Engelska, 2025

AvBalachandar Vellingiri,Mahalaxmi Balachandar

2 199 kr

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Researchers use brain organoids to study the formation of neural tissues, investigate the processes involved in brain development, and gain a better understanding of neurological disorders and diseases. Brain organoids are particularly useful in studying developmental disorders, neurodegenerative diseases, and infectious diseases that affect the brain. Fundamental of Brain Organoids for Neurological Diseases provides a practical resource for researchers on how to utilize and apply brain organoids. This book is organized into nine distinct sections, guiding the reader through each step from advanced overview of what organoids are to the use of brain organoids in various neurodevelopmental disorders and neurodegenerative diseases. In later sections, this book reviews the necessary methods involved in organoid development including the elements and challenges involved. This book will serve as a valuable tool for researchers, helping to advance the understanding of brain biology and disease mechanisms.

Presents the steps involved in the generation of brain organoids from HiPSCs onwards
Summarizes the importance of organoids in understanding various neurodevelopmental disorders
Reviews the ongoing clinical trials using brain organoids
Discusses ethical considerations when conducting organoid research

Produktinformation

Utgivningsdatum2025-10-20
Mått152 x 229 x 19 mm
Vikt580 g
FormatHäftad
SpråkEngelska
Antal sidor360
FörlagElsevier Science
ISBN9780443298981

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Dr. Balachandar Vellingiri currently is investigating various neurological diseases and developing human induced pluripotent stem cells (HiPSCs). Exploring the cutting-edge molecular, cellular, and translational neuroscience approaches, he aims to unravel disease mechanisms, identify therapeutic targets, and develop innovative interventions to slow or reverse neurological diseases. His expertise is on several techniques such as molecular cytogenetics, pathway analysis, and techniques in developing HiPSCs and Brain organoids, especially for neurological diseases. Dr. Mahalaxmi Balachandar is a researcher, currently involved in handling neurological disorder patients and conducting genetic and epigenetic studies. Her expertise is in handling bone marrow derived mesenchymal stem cells (BM-MSCs) as a promising therapeutic agent for LHON disease.

Section I An overview about Organoids1. An overview on organoids - Past, present and future scenario of organoidsSection II Neurodevelopmental disorder2. A brief introduction about neurodevelopmental disorders3. Use of brain organoids for autism4. Role of brain organoids in Rett Syndrome5. Brain organoids in bipolar disorder: Unraveling mechanisms and therapeutic approaches6. Ongoing clinical trials on use of brain organoids for neurodevelopmental disordersSection III Neurodegenerative diseases7. An overview of Neurodegenerative diseases8. Use of brain organoids for Parkinson’s disease and Alzheimer’s disease9. Application of brain organoids in Huntington’s disease10. Ongoing clinical trials on use of brain organoids for neurodegenerative diseases (Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, etc.)Section IV Methods involved in organoids development11. How human-induced pluripotent stem cells are derived into organoids12. Elements required and days involved in organoid generationSection V – Application and advancement of Brain organoids13. Brain organoids – Challenges while constructing organoids14. Existing drug targeting and research using brain organoidsSection VI - Ethical consideration while conducting organoids research15. Ethical consideration while conducting organoids researchSection VII - Future perspective and concluding remarks16. Future directions and conclusion