Functioning of Transmembrane Receptors in Signaling Mechanisms

Ralph A. Bradshaw is Professor Emeritus in the Department of Physiology and Biophysics at the University of California, Irvine. Prior to that he was on the faculty of the Department of Biological Chemistry, Washington University, and Professor and Chair of the Department of Biological Chemistry, University of California Irvine. He presently is Professor of Pharmacology at the University of California, San Diego. He served as president of FASEB, was the founding president of the Protein Society and was the treasurer of the ASBMB. He was the founding editor of Molecular and Cellular Proteomics. His research has focused on protein chemistry and proteomics, with emphasis on the structure and function of growth factors and their receptors, particularly nerve growth factor and fibroblast growth factor, and the involvement of receptor tyrosine kinases in cell signaling. He has also studied the role of proteolytic processing and N-terminal modification in protein stability and turnover. Edward A. Dennis is Distinguished Professor and former Chair of the Department of Chemistry and Biochemistry and Professor in the Department of Pharmacology in the School of Medicine at the University of California, San Diego. He is also Editor-in-Chief of the Journal of Lipid Research.

• 1. Cell Signaling: Yesterday, Today, and Tomorrow2. Structural and Energetic Basis of Molecular Recognition3. Free Energy Landscapes in Protein-Protein Interactions4. Molecular Sociology5. Antibody–Antigen Recognition and Conformational Changes6. Binding Energetics in Antigen–Antibody Interfaces7. Immunoglobulin–Fc Receptor Interactions8. Ig-Superfold and its Variable Uses in Molecular Recognition9. T Cell Receptor/pMHC Complexes10. Mechanistic Features of Cell Surface Adhesion Receptors11. The Immunological Synapse12. NK Receptors13. Carbohydrate Recognition and Signaling14. Rhinovirus–Receptor Interactions15. HIV-1 Receptor Interactions16. Influenza Virus Neuraminidase Inhibitors17. Structural Basis of Signaling Events Involving Fibrinogen and Fibrin18. Structural Basis of Integrin Signaling19. Structures of Heterotrimeric G Proteins and their Complexes20. G-Protein-Coupled Receptor Structures21. Toll-like Receptors – Structure and Signaling22. Variable Lymphocyte Receptors23. Structure and Function of G-Protein-Coupled Receptors: Lessons from Recent Crystal Structures24. Chemokines and Chemokine Receptors: Structure and Function25. The 2 Adrenergic Receptor as a Model for G-Protein-Coupled Receptor Structure and Activation 26. Protease-Activated Receptors27. Agonist-Induced Desensitization and Endocytosis of G-Protein-Coupled Receptors28. Functional Role(s) of Dimeric Complexes Formed from G-Protein-Coupled Receptors29. Chemotaxis Receptors in Bacteria: Transmembrane Signaling, Sensitivity, Adaptation, and Clustering30. An Overview of Ion Channel Structure31. Molecular Mechanism of Store-Operated Ca2+ Signaling and CRAC Channel Activation Mediated 32. Ion Permeation: Mechanisms of Ion Selectivity and Block33. Nicotinic Acetylcholine Receptors34. Ion Channels Regulated by Direct Binding of Cyclic Nucleotides35. Overview of Cytokine Receptors36. Growth Hormone and Prolactin Family of Hormones and Receptors: The Structural Basis for Receptor Activation and Regulation37. Erythropoietin Receptor as a Paradigm for Cytokine Signaling38. The Fibroblast Growth Factor (FGF) Signaling Complex39. Structure of IFN-g and its Receptors40. Structure and Function of Tumor Necrosis Factor (TNF) at the Cell Surface41. The Mechanism of NGF Signaling Suggested by the p75 and TrkA Receptor Complexes42. The Mechanism of VEGFR Activation by VEGF43 . Receptor–Ligand Recognition in the TGFb Superfamily as Suggested by Crystal Structures 44. Insulin Receptor Complex and Signaling by Insulin45. Structure and Mechanism of the Insulin Receptor Tyrosine Kinase46. IL-21 Increased Potency Desig47. Signaling of IL-4R, a Typical Class I Cytokine Receptor: What Defines the Quiescent State?48. Epidermal Growth Factor Kinases and their Activation in Receptor Mediated Signaling49. Tumor Necrosis Factor Receptor-Associated Factors in Immune Receptor Signal Transduction50. Assembly of Signaling Complexes for TNF Receptor Family Molecules51. Mechanisms of CD40 Signaling in the Immune System52. Role of Lipid Domains in EGF Receptor Signaling53. Lipid-Mediated Localization of Signaling Proteins54. Organization of Photoreceptor Signaling Complexes55. Transmembrane Receptor Oligomerization

"This volume reprints 53 articles originally published in by Elsevier in 2010. The researchers describe the structure and role of cell surface receptors in signaling activities with separate sections on tyrosine kinase, cytokine, G protein-coupled, TGFB, TNF, and immunoglobin receptors. The opening chapters review the chemical principles of protein binding, FRET detection techniques, protein tyrosine phosphatases, and the formation of oligomers. Color figures are provided." --Reference and Research Book News