Del 88 - Advances in Pharmacology

From Structure to Clinical Development: Allosteric Modulation of G Protein-Coupled Receptors

Inbunden, Engelska, 2020

AvLangmead,Christopher J,Christopher J. Langmead

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From Structure to Clinical Development: Allosteric Modulation of G Protein-Coupled Receptors, Volume 88, the latest release in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this updated edition include Targeting muscarinic M1 receptor in neurodegeneration, Photo-switchable allosteric ligands, Computational approaches for the design of mGlu receptor allosteric modulators, Allosteric modulation of GLP-1 receptor in metabolic disorders, Group II mGluR roles in the nervous system and their roles in addiction, RAMPs as allosteric modulators of Class B GPCRs, Structure-based discovery and development of mGlu5 NAMs, and much more.

Includes the authority and expertise of leading contributors in pharmacology
Presents the latest release in the Advances in Pharmacology series

Produktinformation

Utgivningsdatum2020-05-08
Mått152 x 229 x undefined mm
Vikt660 g
FormatInbunden
SpråkEngelska
SerieAdvances in Pharmacology
Antal sidor328
FörlagElsevier Science
MedarbetareLangmead,ChristopherJ.
ISBN9780128201879

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The computational modeling of allosteric modulation of metabotropic glutamate receptorsLaura Pérez-Benito, Claudia Llinas del Torrent, Leonardo Pardo and Gary TresadernStructure-based discovery and development of metabotropic glutamate receptor 5 negative allosteric modulatorsKirstie A. Bennett, John A. Christopher and Benjamin G. TehanThe function and allosteric control of the human sweet taste receptorGuy Servant, Terry Kenakin, Lan Zhang, Mark Williams and Nicole ServantThe different aspects of the GABAB receptor allosteric modulationJulie KniazeffRAMPs as allosteric modulators of the calcitonin and calcitonin-like class B G protein-coupled receptorsAugen A. Pioszak and Debbie L. HayStrategies and considerations of G-protein-coupled receptor photopharmacologyAlice E. Berizzi and Cyril GoudetDiscovery and pharmacology of the covalent GLP-1 receptor (GLP-1R) allosteric modulator BETP. A novel tool to probe GLP-1R pharmacologyFrancis S. Willard, Joseph D. Ho and Kyle W. SloopAllosteric modulation of metabotropic glutamate receptors in alcohol use disorder: Insights from preclinical investigationsKari A. Johnson and David M. LovingerAllosteric modulation of muscarinic receptors in alcohol and substance use disordersLeigh C. Walker and Andrew J. LawrenceM1 muscarinic acetylcholine receptors: A therapeutic strategy for symptomatic and disease-modifying effects in Alzheimer's disease? Miriam Scarpa, Sarah Hesse and Sophie J. Bradley