From Genome to Therapy

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• Introduction (J. Venter). Electrophoresis-Based Fluorescent Dideoxy-Terminator Sequencing (J. Efcavitch). Genomic Impact on Pharmaceutical Development (J. Venter). From Transcription Regulation to Cell Cycle Checkpoint (R. Cai, et al.). Mass Spectrometry Resurrects Protein-Approaches in Functional Genomics (M. Mann). A Clinical Molecular Scanner to Study Human Proteome Complexity (D. Hochstrasser, et al.). From Proteomics to Functional Analysis (J. van Oostrum, et al.). Microbial Genome Sequencing: New Insights into Physiology and Evolution (C. Fraser). Pharmacogenetics and Pharmacogenomics in the Discovery and Development of Medicines (A. Roses). Mutagenesis and Genomics in the Mouse: Towards Systematic Studies of Mammalian Gene Function (S. Brown). Biological Annotation of the Drosophila Genome Sequence (G. Rubin). Applications of High-Density Oligonucleotide Arrays (R. Lipshutz). Plasmodium Falciparum: From Genomic Sequence to Vaccines and Drugs (S. Hoffman & D. Carucci). Functional Analysis of the Yeast Genome by Precise Deletion and Parallel Phenotypic Characterization (E. Winzeler, et al.). Patenting Genes and Gene Therapy: Legal and Ethical Aspects (J. Straus). Ethical Issues: From Genome to Therapy (D. Magnus). The Impact of Genomics on Drug Discovery (P. Goodfellow). From Genome to Therapy: Industry Perspective (P. Herrling). Final General Discussion. Indexes.

"It does successfully convey to the reader areas of controversy" (Microbiology Today, November 2001)"there are a number of nuggets in the book that make it worth a browse." (Pharmaceutical Physician, December 2001)"I found this book fun to read." (Biochemistry & Molecular Biology Education, No.29 2001)"Contributors...present 17 papers and the discussions they generated at the symposium." (SciTech Book News, Vol. 25, No. 4, December 2001)