This book constitutes the refereed proceedings of the 10th International Symposium "From Data Models and Back", DataMod 2021, which was held virtually during December 6-7, 2021, as a satellite event of SEFM 2021. The 9 full papers and 1 short paper included in this book were carefully reviewed and selected from 12 submissions. They were organized in topical sections as follows: Model verification; data mining and processing related approaches; and other approaches.