Edited by Hashim U. Ahmed, Division of Surgery and Interventional Science, University College London, London, UK Manit Arya, Department of Urology, University College London, London, UKPeter R. Carroll, Department of Urology, University of California, San Francisco, CA, USAMark Emberton, Division of Surgery and Interventional Science, University College London, London, UK

• Contributor List, vii Preface, xiSection I Is there a role for Focal Therapy in Localised Prostate Cancer?, 11 The Rationale for Focal Therapy of Prostate Cancer, 3Cole Davis, Matthew Cooperberg, and Peter R. Carroll2 Factors That Affect Patients' Choice of Treatment, 11Deb Feldman-Stewart and Michael D. Brundage3 Histological Trends and the Index Lesion in Localized Prostate Cancer, 17Vladimir Mouraviev, Thomas Wheeler, and Thomas J. Polascik4 Selection Criteria for Prostate Cancer Focal Therapy, 29Rajat K. Jain, Timothy K. Ito, and Samir S. TanejaSection II How can we accurately locate cancer within the gland?, 375 Localisation of Cancer within the Gland: Biopsy Strategies, 39Winston E Barzell and Rodrigo Pinochet6 Localisation of Cancer within the Gland: Ultrasound Imaging, 47Ulrich Scheipers7 Localization of Cancer within the Prostate: Dynamic Contrast-Enhanced MRI, 55Philippe Puech, Anwar Padhani, Laurent Lemaitre, Nacim Betrouni, Pierre Colin, and Arnauld Villers8 Localization of Cancer within the Gland: Diffusion-Weighted Magnetic Resonance Imaging of the Prostate, 66Sophie F Riches, Nina Tunariu, and Nandita M deSouza9 The future of Molecular and Biomolecular Imaging in Prostate Cancer, 75Michael S. Gee and Mukesh G. HarisinghaniSection III How can we create discrete tissue necrosis?, 8510 Energies for Focal Ablation: Cryoablation, 87John F. Ward11 Focal Salvage Cryoablation in Recurrent Prostate Cancer, 98Katsuto Shinohara12 High-Intensity Focused Ultrasound, 106Hashim Uddin Ahmed and Mark Emberton13 Energies for Focal Ablation: Photodynamic Therapy, 114Caroline M. Moore, Nimalan Arumainayagam and Mark Emberton14 Focal Therapy for Prostate Cancer Using Radiation, 126Irving Kaplan, Elizabeth Genega and Neil Rofsky15 Image Registration and Fusion for Image-Guided Focal Ablation, 132Dean Barratt and David HawkesSection IV How can we determine the success of Focal Therapy? , 14316 Determining Success of Focal Therapy: Biochemical and Biopsy Strategies, 145Al Barqawi, Paul Maroni, and David Crawford17 Determining Success of Focal Therapy: Imaging, 153Alex Kirkham and Clare Allen18 Evaluating Focal Therapy: Future Perspectives, 170Hashim Uddin Ahmed and Mark EmbertonIndex, 179Colour plate section can be found facing page 116

“Whilst the book is not designed to represent a daily reference guide for the majority of the urological fraternity, it clearly does what it sets out to do; provide an up-to-date and comprehensive analysis of a treatment option that perhaps one day we will routinely consider alongside active surveillance and robotic surgery.”  (Urology News, 1 November 2012)

Edited by Hashim U. Ahmed, Division of Surgery and Interventional Science, University College London, London, UK Manit Arya, Department of Urology, University College London, London, UKPeter R. Carroll, Department of Urology, University of California, San Francisco, CA, USAMark Emberton, Division of Surgery and Interventional Science, University College London, London, UK

• Contributor List, vii Preface, xiSection I Is there a role for Focal Therapy in Localised Prostate Cancer?, 11 The Rationale for Focal Therapy of Prostate Cancer, 3Cole Davis, Matthew Cooperberg, and Peter R. Carroll2 Factors That Affect Patients' Choice of Treatment, 11Deb Feldman-Stewart and Michael D. Brundage3 Histological Trends and the Index Lesion in Localized Prostate Cancer, 17Vladimir Mouraviev, Thomas Wheeler, and Thomas J. Polascik4 Selection Criteria for Prostate Cancer Focal Therapy, 29Rajat K. Jain, Timothy K. Ito, and Samir S. TanejaSection II How can we accurately locate cancer within the gland?, 375 Localisation of Cancer within the Gland: Biopsy Strategies, 39Winston E Barzell and Rodrigo Pinochet6 Localisation of Cancer within the Gland: Ultrasound Imaging, 47Ulrich Scheipers7 Localization of Cancer within the Prostate: Dynamic Contrast-Enhanced MRI, 55Philippe Puech, Anwar Padhani, Laurent Lemaitre, Nacim Betrouni, Pierre Colin, and Arnauld Villers8 Localization of Cancer within the Gland: Diffusion-Weighted Magnetic Resonance Imaging of the Prostate, 66Sophie F Riches, Nina Tunariu, and Nandita M deSouza9 The future of Molecular and Biomolecular Imaging in Prostate Cancer, 75Michael S. Gee and Mukesh G. HarisinghaniSection III How can we create discrete tissue necrosis?, 8510 Energies for Focal Ablation: Cryoablation, 87John F. Ward11 Focal Salvage Cryoablation in Recurrent Prostate Cancer, 98Katsuto Shinohara12 High-Intensity Focused Ultrasound, 106Hashim Uddin Ahmed and Mark Emberton13 Energies for Focal Ablation: Photodynamic Therapy, 114Caroline M. Moore, Nimalan Arumainayagam and Mark Emberton14 Focal Therapy for Prostate Cancer Using Radiation, 126Irving Kaplan, Elizabeth Genega and Neil Rofsky15 Image Registration and Fusion for Image-Guided Focal Ablation, 132Dean Barratt and David HawkesSection IV How can we determine the success of Focal Therapy? , 14316 Determining Success of Focal Therapy: Biochemical and Biopsy Strategies, 145Al Barqawi, Paul Maroni, and David Crawford17 Determining Success of Focal Therapy: Imaging, 153Alex Kirkham and Clare Allen18 Evaluating Focal Therapy: Future Perspectives, 170Hashim Uddin Ahmed and Mark EmbertonIndex, 179Colour plate section can be found facing page 116

“Whilst the book is not designed to represent a daily reference guide for the majority of the urological fraternity, it clearly does what it sets out to do; provide an up-to-date and comprehensive analysis of a treatment option that perhaps one day we will routinely consider alongside active surveillance and robotic surgery.”  (Urology News, 1 November 2012)

Edited by Hashim U. Ahmed, Division of Surgery and Interventional Science, University College London, London, UK Manit Arya, Department of Urology, University College London, London, UKPeter R. Carroll, Department of Urology, University of California, San Francisco, CA, USAMark Emberton, Division of Surgery and Interventional Science, University College London, London, UK

• Contributor List, vii Preface, xiSection I Is there a role for Focal Therapy in Localised Prostate Cancer?, 11 The Rationale for Focal Therapy of Prostate Cancer, 3Cole Davis, Matthew Cooperberg, and Peter R. Carroll2 Factors That Affect Patients' Choice of Treatment, 11Deb Feldman-Stewart and Michael D. Brundage3 Histological Trends and the Index Lesion in Localized Prostate Cancer, 17Vladimir Mouraviev, Thomas Wheeler, and Thomas J. Polascik4 Selection Criteria for Prostate Cancer Focal Therapy, 29Rajat K. Jain, Timothy K. Ito, and Samir S. TanejaSection II How can we accurately locate cancer within the gland?, 375 Localisation of Cancer within the Gland: Biopsy Strategies, 39Winston E Barzell and Rodrigo Pinochet6 Localisation of Cancer within the Gland: Ultrasound Imaging, 47Ulrich Scheipers7 Localization of Cancer within the Prostate: Dynamic Contrast-Enhanced MRI, 55Philippe Puech, Anwar Padhani, Laurent Lemaitre, Nacim Betrouni, Pierre Colin, and Arnauld Villers8 Localization of Cancer within the Gland: Diffusion-Weighted Magnetic Resonance Imaging of the Prostate, 66Sophie F Riches, Nina Tunariu, and Nandita M deSouza9 The future of Molecular and Biomolecular Imaging in Prostate Cancer, 75Michael S. Gee and Mukesh G. HarisinghaniSection III How can we create discrete tissue necrosis?, 8510 Energies for Focal Ablation: Cryoablation, 87John F. Ward11 Focal Salvage Cryoablation in Recurrent Prostate Cancer, 98Katsuto Shinohara12 High-Intensity Focused Ultrasound, 106Hashim Uddin Ahmed and Mark Emberton13 Energies for Focal Ablation: Photodynamic Therapy, 114Caroline M. Moore, Nimalan Arumainayagam and Mark Emberton14 Focal Therapy for Prostate Cancer Using Radiation, 126Irving Kaplan, Elizabeth Genega and Neil Rofsky15 Image Registration and Fusion for Image-Guided Focal Ablation, 132Dean Barratt and David HawkesSection IV How can we determine the success of Focal Therapy? , 14316 Determining Success of Focal Therapy: Biochemical and Biopsy Strategies, 145Al Barqawi, Paul Maroni, and David Crawford17 Determining Success of Focal Therapy: Imaging, 153Alex Kirkham and Clare Allen18 Evaluating Focal Therapy: Future Perspectives, 170Hashim Uddin Ahmed and Mark EmbertonIndex, 179Colour plate section can be found facing page 116

“Whilst the book is not designed to represent a daily reference guide for the majority of the urological fraternity, it clearly does what it sets out to do; provide an up-to-date and comprehensive analysis of a treatment option that perhaps one day we will routinely consider alongside active surveillance and robotic surgery.”  (Urology News, 1 November 2012)