Flavoproteins and Flavoenzymes

After completing studies for the A.B., A.M., and Ph.D. degrees in chemistry at Harvard University, David W. Christianson joined the faculty of the University of Pennsylvania, where he is currently the Roy and Diana Vagelos Professor in Chemistry and Chemical Biology. At Penn, Christianson’s research focuses on the structural and chemical biology of the zinc-dependent histone deacetylases as well as enzymes of terpene biosynthesis. His research accomplishments have been recognized by several awards, including the Pfizer Award in Enzyme Chemistry and the Repligen Award in Chemistry of Biological Processes from the American Chemical Society, a Guggenheim Fellowship, and the Elizabeth S. and Richard M. Cashin Fellowship from the Radcliffe Institute for Advanced Study at Harvard University. Christianson is also a dedicated classroom teacher, and his accomplishments in this regard have been recognized by the Lindback Award for Distinguished Teaching at Penn and a Rhodes Trust Inspirational Educator Award from Oxford University. Christianson has also held visiting professorships in the Department of Biochemistry at Cambridge University and the Department of Chemistry and Chemical Biology at Harvard University. Christianson has served with Prof. Anna Pyle as Co-Editor-in-Chief of Methods in Enzymology since 2015.Dr. Karen N. Allen works at the Department of Chemistry of the Boston University, the Metcalf Center for Science and Engineering Dr. Bruce A. Palfey teaches at the Department of Biological Chemistry of the University of Michigan Medical School, U.S.A.

• 1. Photo-CIDNP as a Probe of Flavoprotein StructureStefan Weber2. Kirisu2 and KiPaD: global analysis of rapid flavoprotein redox kinetics from stopped-flow multi-wavelength absorption spectroscopy dataMilagros Mendina3. A Generic First Approach to Dissecting Flavoenzyme Catalytic CyclesBruce Palfey4. Removing Covalent Constraints of Protein Loops and Lids by a Split-Gene StrategySteve Rokita5. Designing Oxygen Reaction Sites in Flavoprotein DehydrogenasesKaren Allen6. Converting Noncovalent Flavoproteins into Covalently Flavinylated ProteinsMarco Fraaije7. Complexities of Riboflavin BiosynthesisAudrey L. Lamb8. Reactions of Riboflavin CatabolismTadhg Begley9. Ferredoxin-dependent thioredoxin reductaseMilagros Mendina10. Thermophilic Methylenetetrahydrofolate ReductasesMarkos Koutmos11. Ion-Pumping NADH:Quinone OxidoreductaseOscar X. Juárez12. Loading E. coli Dihydroorotate Dehydrogenase with Coenzyme QBruce Palfey13. Single-Component HalogenasesApril Lukowski