Flavonoid Pharmacokinetics

Neal M. Davies, PhD. is Dean of Professor in the Faculty of Pharmacy at the University of Manitoba. He has also held faculty positions at the University of Sydney and Washington State University. Dr. Davies’s research focuses on pharmaceutics and the pharmacokinetics and pharmacodynamics of natural products. He is a graduate of the University of Alberta.Jaime A. Yáñez, PhD. is Senior Study Director in Drug Metabolism and Pharmacokinetics at Alcon Research, Ltd., a Novartis Company. Previously, he worked at Schering-Plough Research Institute and Merck Research Laboratories. He also serves as Adjunct Faculty and Research Consultant at Universities and research organizations in Peru, Mexico, Spain and the United States. Dr. Yáñez’s expertise spans preclinical and clinical pharmacokinetics, pharmacodynamics, pharmaceutics, and predictive computer modeling and simulation, all with an emphasis on natural products.

• Foreword ixPreface xiiiContributors xv1 Polyphenols and Flavonoids: An Overview 1Jaime A. Yáñez, Connie M. Remsberg, Jody K. Takemoto, Karina R. Vega-Villa, Preston K. Andrews, Casey L. Sayre, Stephanie E. Martinez, and Neal M. Davies2 Analysis of Flavonoids through Chromatography 71Jody K. Takemoto, Stephanie E. Martinez, and Neal M. Davies3 Chiral Methods of Flavonoid Analysis 117Jaime A. Yáñez, Casey L. Sayre, Stephanie E. Martinez, and Neal M. Davies4 Preclinical Pharmacokinetics of Flavonoids 161Jaime A. Yáñez, Casey L. Sayre, and Neal M. Davies5 Clinical Pharmacokinetics of Flavonoids 195Casey L. Sayre, Karen D. Gerde, Jaime A. Yáñez, and Neal M. Davies6 Toxicology and Safety of Flavonoids 249Stephanie E. Martinez, Neal M. Davies, and Jonathan K. Reynolds7 Flavonoids and Drug Interactions 281Jaime A. Yáñez, Nagendra V. Chemuturi, Scott W. Womble, Casey L. Sayre, and Neal M. DaviesIndex 321