In this issue of PET Clinics, guest editor Dr. Rakesh Kumar brings his considerable expertise to the topic of FDG-PET Applications in the Management of Patients with Infection and Inflammation. This issue is the third of four that describes the revolutionary impact of FDG-PET on the day-to-day practice of medicine during the past five decades. Top experts discuss key topics, including FDG-PET in myocardial viability and ischemic heart disease; PET in cardiac sarcoidosis; FDG-PET in infective endocarditis and device-related infections; FDG-PET in large vessel vasculitis and aortitis; and many more.