Finns i fler format (1)
GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAA and GABAB receptors. Recently, a novel form of GABAA receptor-mediated inhibition, termed “tonic” inhibition, has been described. Whereas synaptic GABAA receptors underlie classical “phasic” GABAA receptor-mediated inhibition (inhibitory postsynaptic currents), tonic GABAA receptor-mediated inhibition results from the activation of extrasynaptic receptors by low concentrations of ambient GABA. Extrasynaptic GABAA receptors are composed of receptor subunits that convey biophysical properties ideally suited to the generation of persistent inhibition and are pharmacologically and functionally distinct from their synaptic counterparts. This book highlights ongoing work examining the properties of recombinant and native extrasynaptic GABAA receptors and their preferential targeting by endogenous and clinically relevant agents. In addition, it emphasizes the important role of extrasynaptic GABAA receptors in GABAergic inhibition throughout the CNS and identifies them as a major player in both physiological and pathophysiological processes.
Produktinformation
- Utgivningsdatum2016-08-23
- Mått155 x 235 x undefined mm
- Vikt470 g
- FormatHäftad
- SpråkEngelska
- SerieReceptors
- Antal sidor295
- FörlagSpringer-Verlag New York Inc.
- ISBN9781493953219
Tillhör följande kategorier
Hoppa över listan
Du kanske också är intresserad av
Del 27
Extrasynaptic GABAA Receptors
Adam C. Errington, Giuseppe Di Giovanni, Vincenzo Crunelli
Inbunden, 2014
1 489 kr
Del 22
5-HT2C Receptors in the Pathophysiology of CNS Disease
Giuseppe Di Giovanni, Ennio Esposito, Vincenzo Di Matteo
Häftad, 2013
3 859 kr
5-HT2A Receptors in the Central Nervous System
Bruno P. Guiard, Giuseppe Di Giovanni
Häftad, 2019
2 879 kr
Del 172
Serotonin-Dopamine Interaction: Experimental Evidence and Therapeutic Relevance
Giuseppe Di Giovanni, Vincenzo Di Matteo, Ennio Esposito
Inbunden, 2008
4 809 kr
G-Protein-Coupled Receptor Dimers
Katharine Herrick-Davis, Graeme Milligan, Giuseppe Di Giovanni
Inbunden, 2017
2 159 kr
5-HT2A Receptors in the Central Nervous System
Bruno P. Guiard, Giuseppe Di Giovanni
Inbunden, 2018
2 879 kr
Del 22
5-HT2C Receptors in the Pathophysiology of CNS Disease
Giuseppe Di Giovanni, Ennio Esposito, Vincenzo Di Matteo
Inbunden, 2010
2 959 kr
Del 31
mGLU Receptors
Richard Teke Ngomba, Giuseppe Di Giovanni, Giuseppe Battaglia, Ferdinando Nicoletti
Häftad, 2018
2 159 kr
Del 259
5-HT Interaction with Other Neurotransmitters: Experimental Evidence and Therapeutic Relevance Part A
Giuseppe Di Giovanni, Philippe De Deurwaerdere
Inbunden, 2021
4 119 kr
Del 73
Birth, Life and Death of Dopaminergic Neurons in the Substantia Nigra
Giuseppe di Giovanni, Vincenzo Di Matteo, Ennio Esposito
Häftad, 2012
2 969 kr