Extracellular Vesicles for Therapeutic and Diagnostic Applications

• Utgivningsdatum: 2025-01-22
• Mått: 152 x 229 x undefined mm
• Vikt: 920 g
• Format: Häftad
• Språk: Engelska
• Serie: Nanotechnology in Biomedicine
• Antal sidor: 572
• Förlag: Elsevier Science
• ISBN: 9780443238918

• Biokemisk teknik
• Biomedicinsk teknik
• Maskinteknik och material

Dr. Anand Krishnan, Principal Investigator, Department of Haematology and Cell Biology, School of Pathology, Faculty of Health Sciences, University of the Free State, South Africa. He leads the Precision Medicine Integrative Nano Diagnostics (P-MIND) Research Lab, which focuses on the biological functions of extracellular vesicles (EVs) in synthetic biology. His research focuses on establishing an extracellular vesicle (EV) biofoundry by integrating synthetic biology. His research encompasses cell modification, therapeutic target, biomarker discovery from EVs derived from liquid biopsies, and the role of circulating biomarkers in disease development. Dr. Krishnan has authored over 150 articles and edited ten books published by Elsevier, Springer, and Wiley. He received the National Research Foundation (NRF) rating for Next Generation Researchers in South Africa. In the latest list published by Stanford University, Dr. Krishnan was named among the Top 2% of the most influential scientists worldwide. He is an active member of the International Society of Extracellular Vesicles (ISEV), the African Organization for Research and Training in Cancer (AORTIC), and the American Association of Cancer Research (AACR). Recently, he has been serving as an editor for the eLife journal, focusing on the Africa region. Dr. Vadivalagan Chithravel works as a Research Fellow in the Department of Surgery at the University of Michigan, Ann Arbor, specializing in medical science, excluding epidemiology. The Exosome Mediated Signal Transduction Mechanism is his area of expertise. His current work focuses on a glycosylation biomarker associated with an exosome pathway for the physiology of cells with HCC. In addition to being a group director and scientist at the SAARP foundation in India, he has held postdoctoral research fellow positions at Taipei Medical University and China Medical University in Taiwan. He is also an active member of the International Society of Extracellular Vesicles and the American Association of Extracellular Vesicles. Prakash Gangadaran is Visiting Research Professor and Principal Investigator in the Department of Nuclear Medicine, School of Medicine, Kyungpook National University, Republic of Korea. His research focuses on extracellular vesicles and their applications in angiogenesis, wound healing, drug delivery, hair growth, osteoarthritis, and molecular and nuclear imaging. He has led externally funded research projects in extracellular vesicle biology and is actively involved in advancing their translational and therapeutic applications. In addition to his research activities, he is a member of the International Society for Extracellular Vesicles and the Korea Society of Extracellular Vesicles. His work spans the development and evaluation of extracellular vesicle-based approaches for regenerative medicine, imaging, and targeted therapies. Dr. Sathish Muthu is an Assistant Professor in the Department of Orthopaedics at Government Medical College, Karur, India. He is the Co-Founder and Head of Research at Orthopaedic Research Group, a non-profit research organization dedicated to translational orthopaedic research. He is also a steering committee member of the Indian Stem Cell Study Group. and associate member of Knowledge Forum Degenerative of AO Spine. Despite being a board-certified orthopaedic surgeon, Dr. Muthu holds fellowships in spine surgery, orthopaedic rheumatology, and regenerative medicine. He has published over 275 articles in international peer-reviewed journals and has contributed 5 chapters to books on cartilage injury and regeneration. He is also an Associate Editor at various academic journals like PLOS One, Journal of Clinical Medicine, Indian Journal of Orthopaedics, Journal of Orthopaedic Case Reports. His research focuses on cartilage biology, mesenchymal stem cells, exosomes, degenerative disorders, osteoarthritis, and cartilage regeneration. Dr. Ben Peacock is Head of Research at NanoFCM Co., Ltd. He has expertise in exosomal miRNA and protein profiles of EVs from cancer cell lines by RNA-seq and mass spectrometry (ion-trap) with validation by RT-qPCR and further western blotting. In international peer-reviewed journals, he has published more than nine research articles. His research interests include EV research, but he is well established in stromal communication of cancers of the head and neck. Multiple procedures were optimized to maximize EV generation from cell lines, improve concentration and purity of EV isolations, and implement best practices for sample storage.

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