Extracellular Matrix Omics

Sylvie Ricard-Blum is Professor of Biochemistry at the University of Lyon (France). She studies the structure, interactions and functions of the extracellular matrix (ECM) using biochemistry, biophysics, bioinformatics and systems biology. Her laboratory has developed a roadmap and tools to build and contextualize ECM interaction networks, including the database MatrixDB. She has identified several hundreds of ECM interactions, and built interaction networks of ECM proteins, bioactive ECM fragments (matricryptins), glycosaminoglycans and proteoglycans leading to the prediction of new functions for a number of them. Her current research aims at determining the role of intrinsic disorder, cross-linking, proteolysis and mutations in rewiring ECM networks in disease with a focus on matricryptins, lysyl oxidases and syndecans. She has been Secretary and President of the French Society for Matrix Biology, and serves as Associate Editor of Matrix Biology and Matrix Biology Plus, Editor of the newsletter of the International Society for Matrix Biology, and as President of the International Society for Matrix Biology (2019-2020).

• Chapter 1: The extracellular matrix goes - omics: resources and tools.- Chapter 2:The matrisome of model organisms: from in-silico prediction to big-data annotation.- Chapter 3: Detecting changes to the extracellular matrix in liver diseases.- Chapter 4: Characterization of Proteoglycanomes by Mass Spectrometry.- Chapter 5: Historical overview of integrated GAG-omics and proteomics.- Chapter 6: Extracellular matrix networks: from connections to functions.- Chapter 7: Integration of Matrisome Omics: Towards System Biology of the Tumor Matrisome.- Chapter 8: Proteomic and degradomic analysis of body fluids: applications, challenges and considerations.- Chapter 9: Regulation of Cell-Matrix Adhesion Networks: Insights from Proteomics.- Chapter 10: Integrative models for TGF- signaling and extracellular matrix.