This book constitutes the thoroughly refereed proceedings of the 14th International Conference on Designing for a Digital and Globalized World, DESRIST 2019, held Worcester, MA, USA, June 2019. The 20 revised full papers included in the volume were carefully reviewed and selected from 54 submissions. They are organized in the following topical sections: Design Science Research Theory and Methodology; Design Science Research Applications in Healthcare; Design Science Research Applications in Data Science; and Design Science Research Applications in Emerging Topics.