Exosome Communication

Advances in Research and Therapeutics for Health and Disease

Häftad, Engelska, 2024

Av Dalapathi Gugulothu, Dharmendra Kumar Khatri, Lalitkumar K. Vora, William C.S. Cho, Lalitkumar K Vora, William C S Cho

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Exosome Communication: Advances in Research and Therapeutics for Health and Disease serves as a crucial reference for pharmaceutical scientists, focusing on the key qualities of exosomes as drug delivery vehicles. Exosomes are intracellular membrane-based vesicles with diverse compositions, offering significant advantages over traditional drug delivery systems such as liposomes and polymeric nanoparticles, due to their nonimmunogenic nature. This book provides a comprehensive exploration of exosomes, starting with their history and development, understanding extracellular vesicles and biogenesis, and techniques for isolation and characterization. This book also addresses critical considerations like quality control, heterogeneity reduction, regulatory and ethical aspects, clinical trials, and scale-up manufacturing.

Comprehensive Coverage: Detailed exploration of the research history, development, and different isolation techniques of exosomes.
Therapeutic Applications: In-depth discussion of the diverse therapeutic applications of exosomes in health and disease.
Development Challenges: Insightful analysis of the challenges for the development of exosome nanovesicle-based formulations for drug delivery.

Produktinformation

Utgivningsdatum2024-11-15
Mått216 x 276 x 30 mm
Vikt1 180 g
FormatHäftad
SpråkEngelska
Antal sidor586
FörlagElsevier Science
ISBN9780443290527

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Dr. Dalapathi Gugulothu working as Assistant professor, Department of Pharmaceutics , Delhi Institute of Pharmaceutical Sciences and Research, Delhi Pharmaceutical Sciences and Research University , New Delhi. Dr. Dharmendra Kumar Khatri is an Associate Professor in the Department of Pharmacology, NIMS Institute of Pharmacy at NIMS University Rajasthan, Jaipur, India. Dr. Lalitkumar K. Vora is a Lecturer at the School of Pharmacy, Queen’s University, Belfast, and was included in Stanford's top 2% of world scientists list in 2023. Dr. William C. Cho, Highly Cited Researchers in 2023 by Clarivate. Dr. Cho has published over 600 SCI peer-reviewed papers; he is the world's top 0.1% most influential scientists in the world.

1. Introduction: History and Development of Exosomes Nanovesicles2. Exploring Extracellular Vesicles: Understanding Exosomes and Beyond3. Exosome Isolation Techniques: Methods, Protocols, and Best Practices4. Improving Cargo Loading and Release Strategies for Exosomes Nanovesicles5. Exosome Characterization Techniques, Composition Analysis and Contents of Exosomes Nanovesicles: Methods and Interpretation6. Quality Control, Minimizing Heterogeneity and Enhancing Yield in Exosome Isolation and Production7. Inhibition of Cell-Cell Communication in Exosomes8. Modifications of Exosomes Nanovesicles for Targeted drug delivery9. Challenges for the Development of Exosome Nanovesicle-Based Formulations for Drug Delivery and Assessing Toxicity10. Diagnostic Potential and Biomarkers Potential of Exosome Nanovesicles11. Exosomes in Immunology12. Exosomes in Protein and Peptide Delivery13. Exosomes Nanovesicles in Antigen-Specific Antibody Delivery, Gene Delivery, and Vaccine Delivery14. Theranostic Potential of Exosomes in Neurodegenerative Diseases15. Exosomes in Cancer Therapeutic Delivery16. Potential Role of Microbial-derived Exosomes in Human Health and Diseases17. Current Applications of New Generations of Exosomes Nanovesicles18. Clinical Trials and Translational Research in Exosome Nanovesicle Therapeutics19. Scale-up and Manufacturing of Exosome-based Therapeutics20. Regulatory and Ethical Considerations in Exosome-Based Therapeutics