Evolutionary Thinking in Medicine

Alexandra Alvergne is Associate Professor in Biocultural Anthropology at Oxford University and a Fellow of Harris Manchester College in the University of Oxford. She trained as a human behavioural ecologist in France, focusing on the evolutionary and ecological determinants of male reproductive and parental behaviour. She then held a Newton International Fellowship in the Anthropology Department at University College London, where she researched how biological and cultural evolutionary processes intersect in shaping diversity in health decision-making, particularly contraceptive uptake. Now in post at Oxford University, she runs the course “Evolutionary thinking in medicine” for students in Human Sciences (BA), Archeology & Anthropology (BA) and Medical Anthropology (MSc), and she is developing research programs linking evolution, medicine and anthropology. Charlotte Faurie is a CNRS researcher in Human Evolutionary Biology at the Institutefor Evolutionary Sciences in Montpellier University, France. She trained as an evolutionary biologist, focusing on the evolution of the polymorphism of hand preference in human populations. She then held a Marie Curie Post-doctoral Fellowship in the UK, in the Department of Animal and Plant Sciences at Sheffield University, where she investigated the effects of competitive and cooperative interactions among siblings on life-history traits. Back in France, she focused on questions about parental investment, and how sexual selection shapes the evolution of cooperation in humans. She currently leads research programs on human genetic and behavioural adaptations, and on the medicalization of birth. She teaches evolutionary biology and medicine in several master’s programs in France. She is also a student at the Medical School of Montpellier. Crispin Jenkinson is Professor of Health Services Research, and Director of the Health Services Research Unit (HSRU), at the Nuffield Department of Population Health and a Senior Research Fellow of Harris Manchester College in the University of Oxford. He graduated from Bedford College (University of London) before coming to Oxford where he gained an MSc in Psychology and then undertook research on the psychological impact of long-term illness for a DPhil. Prior to joining the HSRU in 1992, he was a research fellow at Nuffield College, Oxford. His main research interests include patient reported outcomes and health status measurement, the evaluation of patient experiences of medical care, and methodology. He has extensive experience of developing and validating outcome measures and, in collaboration with others, has conducted randomised controlled trials in which such instruments have been primary end-points.

• Preface.- Chapter 1: Applying evolutionary thinking in medicine: an introduction.- Chapter 2: “Foetal-maternal conflicts” and adverse outcomes in human pregnancies.- Chapter 3: Obstructed labour: the classic obstetric dilemma and beyond.- Chapter 4: Bottle feeding: the impact on postpartum depression, birth spacing and autism.- Chapter 5: Sudden Infant Death Syndrome.- Chapter 6: The Developmental Origins of Health and Disease: adaptation reconsidered.- Chapter 7: Is calculus relevant to survival? Managing the evolutionary novelty of modern education.- Chapter 8: Binge eating, Disinhibition and obesity.- Chapter 9: Evolutionary aspects of the dietary omega-6/omega-3 fatty acid ratio: medical implications.- Chapter 10: Evolutionary paradigms in cardiology: the case of chronic heart failure.- Chapter 11: Evolutionary imprints on cardiovascular physiology and pathophysiology.- Chapter 12: Darwinian Strategies to Avoid the Evolution ofDrug Resistance During Cancer Treatment.- Chapter 13: Why chemotherapy does not work: cancer genome evolution and the illusion of oncogene addiction.- Chapter 14: Evolution, Infection, and Cancer.- Chapter 15: Microbes, Parasites and Immune diseases.- Chapter 16: Evolutionary principles and Host Defense.- Chapter 17: Helminth immunoregulation and Multiple Sclerosis treatment.- Chapter 18: Inflammaging and its role in ageing and age-related diseases.- Chapter 19: Dementias of the Alzheimer type: views through the lens of evolutionary biology suggest amyloid-driven brain aging is balanced against host defence.- Chapter 20: The Evolutionary Etiologies of Autism Spectrum and Psychotic-Affective Spectrum Disorders.- Chapter 21: Why are humans vulnerable to Alzheimer's Disease?.- Chapter 22: Evolutionary approaches to depression: prospects and limitations.- Chapter 23: The ups and downs of placebos.

“This book challenges the current thinking on some of the basics of disease. … This is a book for the visionaries and researchers in medicine, to provoke thought and expand the realm of possibilities for future research. … this is a book for those whose careers are more focused on questioning the status quo and where medicine should be headed. For all its controversial ideas, it is a very interesting and thought-provoking book.” (Vincent F. Carr, Doody's Book Reviews, March, 2016)