This book constitutes the refereed post-conference proceedings of the 19th International Conference on Evaluation of Novel Approaches to Software Engineering, ENASE 2024, held in Angers, France, during April 28–29, 2024.The 16 full papers and 6 short papers presented in this book were carefully reviewed and selected from 128 submissions. They are organized into the following topical sections : Theory and Practice of Systems and Applications Development; Challenges and Novel Approaches to Systems and Software Engineering (SSE); Systems and Software Quality; and Systems and Software Engineering (SSE) for Emerging Domains.