Eukaryotic RNases and their Partners in RNA Degradation and Biogenesis

Dr Guillaume Chanfreau obtained his Bachelor Degree from Université Claude Bernard Lyon and ENS Lyon and his PhD in Microbiology from Université Paris VI. During his PhD, mentored by Alain Jacquier, he characterized the mechanism of splicing of group II intron ribozymes. Dr Chanfreau then completed postdoctoral training at UCSF with Christine Guthrie, where he identified novel factors involved in 3’-end processing of mRNAs and small RNAs. After this postdoctoral training, he was recruited at UCLA as a professor in the Department of Chemistry and Biochemistry where he teaches a Biochemistry upper division course focused on DNA, RNA and protein synthesis. At UCLA, Dr Chanfreau has developed a research program focused on understanding the mechanisms of RNA degradation and RNA processing, and how these processes contribute to regulate gene expression. Fuyu Tamanoi is a biochemist who has served on the UCLA School of Medicine and UCLA College faculty since he joined the Department of Microbiology, Immunology & Molecular Genetics in 1993. He became a full professor in 1997.

• Biochemistry and Function of RNA ExosomesMichal Lubas, Aleksander Chlebowski, Andrzej Dziembowski and Torben Heick Jensen Plant Exosomes and CofactorsHeike Lange and Dominique GagliardiStructure and Activities of the Eukaryotic RNA Exosome Elizabeth V. Wasmuth and Christopher D. LimaTRAMP Stimulation of ExosomePeter Holub and Stepanka VanacovaXRN1: A Major 5’ to 3’ Exoribonuclease in Eukaryotic Cells Sarah Geisler and Jeff Coller Structures of 5’-3’ Exoribonucleases (XRNs)Jeong Ho Chang, Song Xiang and Liang TongThe Diverse Functions of the Nuclear Rat1/Xrn2 ExonucleaseMichal Krzyszton, Monika Zakrzewska-Placzek, Michal Koper and Joanna KufelNormal and Aberrantly Capped mRNA Decapping Megerditch Kiledjian, Mi Zhou and Xinfu JiaoActivity and Function of DeadenylasesChristiane Harnisch, Bodo Moritz, Christiane Rammelt, Claudia Temme and Elmar WahleThe Diverse Functions of Fungal RNase III Enzymes in RNA Metabolism Kevin Roy and Guillaume F. Chanfreau