Del i serien Oxford Series in Behavioral Neuroendocrinology

Estrogens and Memory

Basic Research and Clinical Implications

Inbunden, Engelska, 2020

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Estrogens are key modulators of brain regions that mediate learning and memory formation. This regulation has significant translational implications, as estrogens contribute to age-related memory decline and dementia, emotional disorders, addiction, and recovery from brain injury. Although the importance of estrogens for memory formation has been well accepted within the behavioral neuroendocrinology community, it has yet to be fully appreciated by neuroscientists outside of the discipline.Recent National Institutes of Health policies on the inclusion of sex as a biological variable in grant applications will force thousands of researchers to consider hormonal regulation of memory for the first time. However, the majority of these researchers are not trained endocrinologists, and no previous monograph comprehensively encompasses the breadth of basic and clinical research on this subject. Thus, this book provides a vital resource for non-endocrinologists and endocrinologists alike.Estrogens and Memory: Basic Research and Clinical Implications provides a compendium of cutting-edge basic and clinical research describing the ways in which estrogens regulate memory in a variety of species. Chapters are written by leading experts whose work is on the forefront of this exciting field. Three fundamental discussions focus on: effects of estrogens on the hippocampus and other brain regions central to memory, effects of estrogens on memory and related cognitive processes throughout the lifespan, and translational implications of estrogenic regulation of memory for aging and disease.

Produktinformation

Utgivningsdatum2020-02-20
Mått257 x 183 x 30 mm
Vikt1 089 g
FormatInbunden
SpråkEngelska
SerieOxford Series in Behavioral Neuroendocrinology
Antal sidor516
FörlagOUP USA
ISBN9780190645908

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Endokrinologi inom Medicin

Contributors IntroductionKaryn M. Frick Part I Estrogen effects on the hippocampus and related brain regions 1. Estrogen receptor distribution in the hippocampus and prefrontal cortex Annelyn Torres-Reveron, Wayne G. Brake, and Teresa A. Milner 2. Estrogen receptors at the membrane: Interactions with metabotropic glutamate receptors and caveolin proteins regulated through palmitoylationKatherine R. Tonn, Paul G. Mermelstein, and John Meitzen 3. Rapid effects of estradiol on dendritic spines and synaptic plasticity in the male and female hippocampusAsami Kato, Gen Murakami, Yasushi Hojo, Sigeo Horie and Suguru Kawato 4. Rapid modulation of spinogenesis by estradiol in the neocortex: An emerging role for GPER?Deepak P. Srivastava, Katherine J. Sellers, Peter D. Evans 5. Estrogenic regulation of synaptic actin proteins and plasticityEnikö A. Kramár 6. Hippocampal synaptic stability and plasticity: The role of hippocampus-derived estradiol Gabriele M. Rune 7. Estrogenic regulation of glia and neuroinflammationAndrea Crespo-Castrillo, Maria Angeles Arevalo, Luis M. Garcia-Segura, and Natalia Yanguas-Casás Part II Estrogenic regulation of memory and related cognitive processes throughout the lifespan 8. Molecular mechanisms underlying rapid effects of estradiol on memory consolidationKaryn M. Frick, Jaekyoon Kim, Wendy Koss, and Jennifer J. Tuscher 9. Estrogenic regulation of spatial memory in songbirdsDavid J. Bailey and Colin J. Saldanha 10. Estrogenic regulation of recognition memory and spinogenesisVictoria N. Luine and Maya Frankfurt 11. Who are you and what do you know? Estrogenic regulation of social recognition and social learning Paul A.S. Shepard, Talya Kuun, Pietro Paletta, and Elena Choleris 12. Estrogens have their ups and downs: A multiple memory systems approach to the bidirectional effects of estrogens on learning strategy Donna L. Korol 13. Puberty: Effects on the prefrontal cortex and cognitive behaviorJanice M. Juraska 14. Ovarian hormones, cognition, and reproductive aging: Applications and implications for translating preclinical endocrine brain research to the clinicAlesia A. Prakapenka, Veronica Pena, Heather A. Bimonte-Nelson 15. Estrogenic regulation of hippocampal neurogenesis throughout the lifespanShunya Yagi, Rand Mahmoud, Wansu Qiu, Paula Duarte-Guterman, and Liisa A.M. Galea 16. Effects of estradiol on basal forebrain cholinergic neurons and their impact on cognitive performance and age-related cognitive decline Robert B. Gibbs 17. Estrogenic regulation of synaptic health and cognition in aging rhesus monkeys Johanna L. Crimins, Yuko Hara, John H. Morrison Part III Translational implications of estrogenic regulation of memory for aging and disease 18. Hormone therapy in postmenopausal women: The Women's Health Initiative Memory Study and its continuing impact on research and practiceIra Driscoll, Stephen R. Rapp, Karen C. Johnson, Mark A. Espeland 19. Estrogen treatment in Alzheimer's disease: Translational implications of estrogenic regulation of memory for aging and diseaseKelly N. Morgan and Carey E. Gleason 20. Effects of dietary estrogens on dementiaShelina Kassam, Mira Soni, Eef Hogervorst 21. Oral contraceptive effects on cognitionSoniya Assudani Patel, Courtney McQuade, Robert S. Astur 22. Effects of SERMS and antiestrogens on cognition in women with breast cancerJeffrey D. Blaustein 23. Estrogen neuroprotection and anti-inflammation actions in the hippocampusRoshni D. Thakkar, Ruimin Wang, Gangadhara R. Sareddy, Ratna K. Vadlamundi, and Darrell W. Brann 24. Estrogenic regulation of neuroprotection and inflammation in ischemic stroke and agingFarida Sohrabji, Shameena Bake, Amutha Selvamani 25. Estradiol and fear generalization: Implications for anxiety disordersAaron M. Jasnow, Jordan M. Adkins, and Joseph F. Lynch III 26. Role of estrogens in addiction-related learningHanna Yousuf Part IV Conclusions and Future Directions 27. Moving forward: A vision for future research on estrogenic regulation of memoryKaryn M. Frick Index

Estrogens and Memory: Basic Research and Clinical Implications provides a very important, current overview of a field that has opened up the brain as an important target of sex hormones that affect cognitive, emotional, and motor functions throughout the brain and not just reproduction. The book includes chapters by leading researchers on this topic and covers basic molecular and behavioral mechanistic studies as well as clinical findings."