Essentials of Chemical Biology

Structures and Dynamics of Biological Macromolecules In Vitro and In Vivo

Häftad, Engelska, 2024

AvAndrew D. Miller,Julian A. Tanner,UK) Miller, Andrew D. (Mendel University, Brno, Czech Republic; Imperial College, London,Julian A. (University of Hong Kong) Tanner,Andrew D Miller,Julian A Tanner

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Essentials of Chemical Biology Discover a detailed knowledge of concepts and techniques that shape this unique multi-discipline Chemical Biology is devoted to understanding the way that Biology works at the molecular level. This is a problem-driven multi-discipline, incorporating as it does Organic, Physical, Inorganic, and Analytical Chemistry alongside newer emerging molecular disciplines. In recent years, Chemical Biology has emerged as a vibrant and growing multi-discipline distinct from Biochemistry that is focused on the quantitative analyses of the structures and functions of biological macromolecules and macromolecular lipid assemblies, at first in isolation, then in vitro and in vivo. The second edition of the Essentials of Chemical Biology begins with a thorough introduction to the structure of biological macromolecules and macromolecular lipid assemblies, before moving on to the principles of chemical and biological synthesis, followed by descriptions of a comprehensive variety of research techniques and experimental methods. In addition, the second edition now includes new sections on the behaviour of biological macromolecules and macromolecular lipid assemblies in cells in vitro and in organisms in vivo. Given this, the second edition of the Essentials of Chemical Biology promises to cement itself as the leading introduction to Chemical Biology, incorporating descriptions of cutting-edge research wherever appropriate. Hence, readers of the second edition of the Essentials of Chemical Biology will find: a general expansion in understanding of basic molecular mechanisms in Biology moving towards cellular and organismal mechanismsentirely new chapters covering miniaturization and array technologies, Chemical Cell Biology, and the interface between Chemical Biology and Nanotechnologyupdates to chapters reflecting recent research developmentsan increased engagement with medical applicationsEssentials of Chemical Biology is ideal for advanced undergraduates or (post) graduate students in Chemical Biology and adjacent fields.

Produktinformation

Utgivningsdatum2024-02-02
Mått213 x 274 x 25 mm
Vikt1 111 g
FormatHäftad
SpråkEngelska
Antal sidor560
Upplaga2
FörlagJohn Wiley & Sons Inc
ISBN9781119437970

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Biologi inom Naturvetenskap och teknik

Andrew D. Miller, PhD, is currently Professor of Organic Chemistry and Chemical Biology at Mendel University in Brno, Czech Republic, and founder/CSO of KP Therapeutics (Europe) s.r.o., a nanomedicine and precision therapeutics company, also based in the Czech Republic. Julian A. Tanner, PhD, is a Professor of the School of Biomedical Sciences, Assistant Dean of the LKS Faculty of Medicine, and Director of the Common Core at the University of Hong Kong.

Preface xGlossary of Physical and Chemical Terms xiiAbout the Companion Website xviii1 The Structures of Biological Macromolecules and Lipid Assemblies 11.1 General introduction 11.2 Protein structures 31.3 Carbohydrate structures 201.4 Nucleic acid structures 311.5 Macromolecular lipid assemblies 531.6 Structural forces in biological macromolecules 602 Chemical and Biological Synthesis 682.1 Introduction to synthesis in chemical biology 682.2 Chemical synthesis of peptides and proteins 682.3 Chemical synthesis of nucleic acids 752.4 Chemical synthesis of oligosaccharides 842.5 Chemical synthesis of lipids 872.6 Biological synthesis of biological macromolecules 892.7 Directed biological synthesis of proteins 972.8 Biological syntheses of nucleic acids, oligosaccharides and lipids 1023 Molecular Biology as a Toolset for Chemical Biology 1043.1 Key concepts in molecular biology 1043.2 Tools and techniques in molecular biology 1083.3 Cloning and identification of genes in DNA 1173.4 Integrating cloning and expression 1233.5 Site-directed mutagenesis 1254 Electronic and Vibrational Spectroscopy 1284.1 Electronic and vibrational spectroscopy in chemical biology 1284.2 Ultraviolet-visible spectroscopy 1284.3 Circular dichroism spectroscopy 1344.4 Vibrational spectroscopy 1384.5 Fluorescence spectroscopy 1414.6 Probing metal centres by absorption spectroscopy 1635 Magnetic Resonance 1645.1 Magnetic resonance in chemical biology 1645.2 Key principles of NMR 1645.3 Two-dimensional NMR 1765.4 Multidimensional NMR 1805.5 Biological macromolecule structural information 1835.6 Electron paramagnetic resonance spectroscopy: key principles 1936 Diffraction and Microscopy 1996.1 Diffraction and microscopy in chemical biology 1996.2 Key principles of X-ray diffraction 1996.3 Structural information from X-ray diffraction 2066.4 Neutron diffraction 2166.5 Key principles of electron microscopy 2176.6 Key principles of scanning probe microscopy 2247 Molecular Recognition and Binding 2327.1 Molecular recognition and binding in chemical biology 2327.2 Theoretical models of binding 2457.3 Analysing molecular recognition and binding 2517.4 Biological molecular recognition studies 2638 Kinetics and Catalysis 2788.1 Catalysis in chemical biology 2788.2 Steady state kinetic schemes 3008.3 Pre-steady-state kinetics 3238.4 Theories of biocatalysis 3288.5 Electron transfer 3469 Mass Spectrometry and Proteomics 3489.1 Mass spectrometry in chemical biology 3489.2 Key principles in mass spectrometry 3499.3 Structural analysis of biological macromolecules and lipids by mass spectrometry 3599.4 The challenge of proteomics 3689.5 Genomics: assigning function to genes and proteins 37510 Molecular Selection and Evolution 37810.1 Chemical biology and the origins of life 37810.2 Molecular breeding: natural selection acting on self-organisation 38310.3 Directed evolution of protein function 38510.4 Directed evolution of nucleic acids 39010.5 Catalytic antibodies 39811 Chemical Biology of Cells 40111.1 General introduction 40111.2 Array technologies, microfluidics and miniaturisation 40111.3 Chemical genetics and potential new therapeutics 40311.4 Chemical cellular dynamics 41211.5 Chemical biology and in vivo cell connectomics 41512 Chemical Biology of Stem Cells to Tissue Engineering 42112.1 General introduction 42112.2 Chemical stem cell biology 42112.3 The road to cell therapies 43712.4 Tissue engineering 43913 Chemical Biology, Nanomedicine and Advanced Therapeutics 44113.1 General introduction 44113.2 The chemical biology approach to gene therapy 44113.3 Biophysical characterisation of LNPs 46713.4 Applications of LNPs with small molecule drugs 47114 Chemical Biology and Advanced Diagnostics Leading to Precision Therapeutic Approaches 47214.1 General introduction 47214.2 MRI basic principles leading to diagnostic applications 47214.3 PET/CT and SPECT fundamentals 47714.4 Understanding how to control nanoparticle biodistribution behaviour in vivo 47814.5 Theranostics 47915 DNA Nanotechnology 48915.1 Background 48915.2 Three-dimensional DNA nanostructures 49115.3 Dynamic DNA nanostructures 49615.4 Biomedical applications of DNA nanostructures 500Bibliography 502Index 519