Essentials of Carbohydrate Chemistry and Biochemistry

Häftad, Engelska, 2026

AvThisbe K. Lindhorst

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Thoroughly updated edition of the leading textbook on carbohydrate chemistry From synthesis to biological function, Essentials of Carbohydrate Chemistry and Biochemistry introduces the entire range of modern carbohydrate chemistry and chemical biology. In this new edition, the increasing recognition of the role of carbohydrates in biology, pharmacology, and medicine is reflected in greatly expanded sections on glycobiology and glycomimetics. The new edition also features a new set of illustrations, many of which are now in color, as well as intriguing practical examples and story-telling text boxes providing context for the relevance of carbohydrates in science and society. Didactically written by an experienced lecturer and graduate student advisor, Essentials of Carbohydrate Chemistry and Biochemistry includes information on: Protecting groups for carbohydrates, including protection of the anomeric center, acyl, ether, and acetal protecting groupsMethods for the analysis of carbohydrates, covering polarimetry, NMR spectroscopy, and mass spectrometryImportant modifications and functionalizations of the sugar ring, such as deoxy derivatives, anhydro sugars, and epimerizationsPrincipal approaches to the chemical and enzymatic synthesis of glycosides and glycopeptides, and modern examples of advancing the art of glycoside synthesis employing solution as well as solid phase methodsStructural diversity and biosynthesis of oligosaccharides and glycoconjugatesA greatly expanded section on glycobiology that focuses on the role of carbohydrates in membrane architecture, cell-cell-recognition. cell adhesion, and their biomedical applicationsUpdated and thoroughly modernized for more efficient classroom teaching and self-learning, the Fourth Edition of Essentials of Carbohydrate Chemistry and Biochemistry is essential reading for students in chemistry, biochemistry, biotechnology, and pharmacy with an interest in glycochemistry and glycobiology.

Produktinformation

Utgivningsdatum2026-06-24
Mått170 x 244 x undefined mm
FormatHäftad
SpråkEngelska, Tyska
Antal sidor384
Upplaga4
FörlagWiley-VCH Verlag GmbH
ISBN9783527350636

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Biokemi inom Naturvetenskap och teknik
Biokemisk teknik inom Naturvetenskap och teknik

Thisbe K. Lindhorst is Full Professor at the Faculty of Mathematics and Natural Science of Christiana Albertina University of Kiel (Germany), where she holds a chair in Organic and Biological Chemistry. She studied chemistry at the Universities of München and Münster and received her Ph.D. in Organic Chemistry in 1991 from the University of Hamburg. Her scientific interests are in the field of synthetic organic chemistry and in biological chemistry, especially in glycochemistry and glycobiology. She served as elected president of the German Chemical Society (GDCh) in 2016-2017.

Preface of the Fourth Edition ixPreface of the Third Edition xiPreface of the Second Edition xiii1 Structure of Saccharides 11.1 Structure of Monosaccharides 11.2 Structure of Oligosaccharides 241.3 Structure of Polysaccharides 301.4 Nomenclature of Saccharides 342 Protecting Groups for Carbohydrates 452.1 Acyl Protecting Groups 472.2 Ether Protecting Groups 572.3 Selective Protection of the Primary Hydroxyl Group 622.4 Cyclic Protecting Groups 652.5 Orthoesters as Protecting Groups 812.6 Protection of the Anomeric Centre 832.7 One-Catalyst–One-pot Protections of Per-silylated Sugars 872.8 N-Protection for Amino Sugars 892.9 Enzymes in Protecting Group Chemistry 932.10 Strategic Protecting-Group Sequences on Carbohydrate Scaffolds 943 O-Glycoside Synthesis 1093.1 1,2-trans and 1,2-cis Glycosidation 1143.2 Factors that Influence a Glycosylation Reaction 1173.3 The Koenigs–Knorr Method 1193.4 Glycosyl Acetimidates 1253.5 Thioglycosides 1313.6 n-Pentenyl Glycosides 1363.7 Gold-Catalysed Glycoside Synthesis 1403.8 Synthesis of 2-Deoxy Glycosides 1433.9 Synthesis of α-D-Glucosides and β-D-Mannosides 1473.10 Synthesis of 2-Acetamido-2-Deoxy Glycosides 1543.11 Solid-Phase Oligosaccharide Synthesis 1613.12 Glycoside Synthesis Employing Enzymes 1633.13 Glycosylation Strategies 1704 Important Modifications of the Sugar Ring 1874.1 Activation–Substitution Reactions at the Carbohydrate Ring: Deoxyhalo Derivatives 1874.2 Deoxygenation of Carbohydrates 1984.3 Epimerisations 2024.4 From Azido to Amino and More: N-Functionalised Sugars 2054.5 Important Unsaturated Saccharides 2084.6 Unexpected Journeys of Sugars 2195 Structure and Biosynthesis of Glycoconjugates 2335.1 Size, Diversity and Representation 2335.2 Structures of Glycoconjugates 2365.3 Biosynthesis of Oligosaccharides 2606 Glycobiology 2816.1 The Glycocalyx 2826.2 The Lectins 2846.3 Carbohydrate Microarrays 2946.4 Glycomimetics and Carbohydrate Drugs 2966.5 Microbial Adhesion—FimH Antagonists and Catch Bonds 3086.6 The Clinical Impact of Glycobiology 3146.7 Biochemical Engineering 3246.8 Glycan Atlassing 333References 335In a Nutshell 345Key Terms 345Index 347