Essential Guide to Neurodegenerative Disorders

Mechanistic, Diagnostic and Therapeutic Advances

Häftad, Engelska, 2024

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Handbook of Neurodegenerative Disorders: Mechanism, Diagnostic and Therapeutic Advances provides a comprehensive review on the current biomedical studies aimed at identifying the underlying causes of neurodegeneration. This book reviews the most recent developments in molecular and cellular processes altered during neurodegeneration. Divided into four parts, the first covers the mechanism of cell death in neurodegeneration. The second section reviews the recent progress in gene and gene products in neurodegeneration, including Huntington's disease, Parkinson's disease, Friedreich' s ataxia, and spinal muscular atrophy. The final sections cover the current and future diagnostic techniques of neurodegenerative disorders along with therapeutic approaches.

Reviews big data and neurodegeneration disorders, including gene mapping
Examines the structural basis of protein assembly into amyloid filaments in neurodegenerative disease
Covers the progress and challenges of pharmacotherapy of neurodegenerative disorders

Produktinformation

Utgivningsdatum2024-11-28
Mått191 x 235 x 33 mm
Vikt1 880 g
FormatHäftad
SpråkEngelska
Antal sidor700
FörlagElsevier Science
ISBN9780443157028

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Dr. Wael Mohamed is Professor of Basic Medical Science at the International Islamic University Malaysia. He obtained his MD and MSc in Clinical Pharmacology from Meoufia Medical School, Egypt, and his PhD in Neuroscience from The Pennsylvania State University. After finishing his neurosurgery training, he began his career as a clinical pharmacologist with psychopharmacology as a subspecialty. Dr. Mohamed specializes in translational brain research and brings more than two decades of experience to the project. His current focal area is the investigation and development of novel treatments for Alzheimer’s Disease and Parkinson’s Disease. He is a member of several key basic and clinical neuroscience societies, including the American Psychological Association, The Society for Neuroscience, National Academy of Neuropsychology, and the International Congress of Neuropsychopharmacology. Dr. Mohamed brings prior book editing experience from Elsevier titles including Pharmacotherapy of Parkinson’s Disease; Essential Guide to Neurodegenerative Disorders; Translational Models of Parkinson’s Disease and related Movement Disorders; and Telehealth in Movement Disorders.

Part-I: Mechanism of cell death in neurodegeneration1. Pathways in AD2. Shared signalling pathways in Alzheimer’s and metabolic disease3. Abeta pathology in AD and its potential to seed and propagate4. Single-cell approaches to identify shared and distinct signatures across neurodegenerative diseases5. Modelling of neurodegenerative disease using brain organoids6. The structural basis of protein assembly into amyloid filaments in neurodegenerative disease-Benjamin7. Blood brain barrier in neurodegenerative disorders8. Protein misfolding in neurodegeneration9. Neuroinflammation and neurodegeneration10. Gut-Brain Axis in neurodegeneration11. Modelling Neural Circuits in Parkinson’s Disease12. Neuropathology of Parkinsonism in Alzheimer’s Disease13. Huntington Disease updates14. Neuroinflammation in neurodegenerationPart-II: Gene and gene products in neurodegeneration15. Big data and neurodegeneration disorders16. Genomics and PD17. RNA Binding Proteins and the Genesis of Neurodegenerative Diseases-Ahmed Moustafa, Egypt18. Molecular Genetics of Huntington’s Disease19. neuronopathic LSDs: opportunities and challenges20. Nutrigenomics and PD21. Genes and MS: updates22. Genetic mapping and big data in ALSPart-III: Present and future diagnostic approaches of neurodegenerative disorders23. Biomarkers in AD24. Biomarkers of PD25. HMGB complex in PD diagnosis26. Psychological assessment of PD patientsPart-IV: Present and future therapeutics of neurodegenerative disorders27. Pharmacotherapy of neurodegenerative disorders: challenges and hopes28. Advanced Drug Delivery Nanosystems: Perspectives and Regulatory Issues29. Towards the Development of a Device to Improve the Gait of Patients Suffering from Parkinson’s Disease30. Developing Antisense Therapies for Neurodegenerative Diseases31. Advances in Gene Therapies for the CNS32. Nutrition and PD33. Stem cell therapy in NDG disorders