Peter B. Cotton, MD, FRCP, FRCS, is Professor of Medicine and Director of the Digestive Disease Centre, Medical University of South Carolina, Charleston, SC, USA. Joseph W. Leung, MD, FRCP, FACP, MACG, FASGE, is Professor of Medicine, Department of Gastroenterology and Hepatology, University of California, Davis School of Medicine, Sacramento; and Chief of Gastroenterology, VA Northern California Health Care System, GI Unit, Sacramento VAMC, Mather, CA, USA.