Epigenetics in Health and Disease

Prof. Vijai Singh is currently serving as Head of the Department of Biosciences, School of Science and Dean (Research & Innovation) at Indrashil University, Rajpur, Mehsana, India. Prior to this, he held the position of Associate Professor in the same department at Indrashil University. He has also served as Assistant Professor in the Department of Biological Sciences and Biotechnology at the Institute of Advanced Research, Gandhinagar, and in the Department of Biotechnology at the Invertis University, Bareilly, India. Earlier of his career, Prof. Singh worked as a Postdoctoral Fellow in the Synthetic Biology Group at the Institute of Systems and Synthetic Biology, Paris, France and at the School of Energy & Chemical Engineering at the Ulsan National Institute of Science and Technology, Ulsan, South Korea. He earned his Ph.D. in Biotechnology in 2009 from the ICAR-National Bureau of Fish Genetic Resources, Uttar Pradesh Technical University, Lucknow, India. His doctoral research focused on the development of molecular and immunoassays for the diagnosis of Aeromonas hydrophila. Prof. Singh’s research interests lies in the design and construction of novel biosynthetic pathways for production of medically and industrially important biomolecules. His laboratory is also actively engaged in developing CRISPR-Cas systems for gene knock out, knock in, gene regulation and diagnostic. With over 15 years of research and teaching experience, his areas of expertise include synthetic biology, metabolic engineering, bioinformatics, microbiology, and industrial microbiology. He has an extensive academic record, with over 110 articles, 89 book chapters, 26 books and 3 patents to his credits. Prof. Singh has received number of prestigious awards, including the Bioclues Innovation, Research and Development Award (2023) from the BIOCLUES Society, the Vice Chancellor's Best Research Award (2023) from Indrashil University, and the Agathiyar Chemical Biology Award (2023) from the Society of Chemical and Synthetic Biology. At Indrashil University, he currently serves as chairman of the Board of Study, and is a member of the Academic Council of Indrashil University. He also holds the position of the Member Secretary of the Institutional Biosafety Committee (IBSC) at the university. Dr. Singh is actively involved in national and international scientific advisory roles. Dr. Indra Mani is an Assistant Professor in the Department of Microbiology, Gargi College, University of Delhi (DU), New Delhi, India. He received M.Sc. in Microbiology from Bundelkhand University (BU), Jhansi, UP, India and Ph.D. in Biochemistry from Banaras Hindu University (BHU), Varanasi, UP, India. He completed postdoctoral training in the Department of Physiology, School of Medicine, Tulane University, New Orleans, USA. He has also worked as a Senior Research Officer (SRO) in the Department of Medicine, All India Institute of Medical Sciences (AIIMS), New Delhi, India. He has more than 10 years of research and teaching experience in Microbiology, Molecular Genetics, Cell Signaling, and Bioinformatics. He has published 49 articles in peer reviewed journals and 22 book chapters. He has presented several papers in the different national and international conferences. He has extensive experience in fluorescence/confocal microscopy, receptor internalization, trafficking and signaling, molecular cytogenetics, microbial characterization, and in silico analysis. He serves as a reviewer of peer-reviewed journals and also a member of national and international societies.

• PrefaceIndra Mani and Vijai Singh1. Insight into epigenetics and human diseasesAnkita Saini, Adya Varshney, Ashok Saini and Indra Mani2. State-of-the-art techniques to study epigeneticsAshok Saini, Yashaswi Rawat, Kritika Jain and Indra Mani3. Mechanisms of DNA methylation and histone modificationsSantoshi Acharjee, Shraddha Chauhan, Rajshree Pal and Raghuvir Singh Tomar4. Epigenetics, genomics imprinting and non-coding RNAsGautham Manoj, Anjali Krishna, Anandhu Presannan, Nidheesh M, Renuka Suravajhala and Prashanth Suravajhala5. Epigenetics in cardiovascular health and diseaseNicholas W.S. Chew, Shaun Loong and Roger Foo6. Histone modifications in fat metabolism and obesityDinh-Toi Chu, Yen-Vy Nguyen Thi and Nicholas W.S. Chew7. Role of DNA methylation in diabetes and obesityDinh-Toi Chu, Nhat-Le Bui, Hue Vu Thi and Yen Vy Nguyen Thi8. Epigenetic regulation of agingSarita Mishra, Mahima Raval, Akanksha Singh Kachhawaha, Budhi Sagar Tiwari and Anand Krishna Tiwari9. Epigenetics in fetal alcohol spectrum disorderBalapal S. Basavarajappa10. Epigenetic regulation of pluripotency inducer genes NANOG and SOX2 in human prostate cancerNiharika, Ankan Roy, Jagdish Mishra, Subhajit Chakraborty, Suraj Pratap Singh and Samir Kumar Patra11. Mechanistic aspects of reversible methylation modifications of arginine and lysine of nuclear histones and their roles in human colon cancerAnkan Roy, Niharika, Subhajit Chakraborty, Jagdish Mishra, Suraj Pratap Singh and Samir Kumar Patra

"...in depth coverage of basic to applied aspects in the pathogenesis and management of [epigenetic modulation]…. [An] interesting and informative book [that] describes the epigenetic modifications associated with cancer and neurological, cardiovascular, renal, and metabolic disorders... [U]nique in providing currently updated information related to epigenetics in health and disease. Students and research scientists, clinicians in the fields of neurology, cardiology, and nephrology, and others interested in the subject will find this book very useful." --©Doody’s Review Service, 2023, Omer Iqbal, MD, FACC, FESC (Loyola University Medical Center)