Del 11 i serien Translational Epigenetics

Epigenetics and Regeneration

Inbunden, Engelska, 2019

2 459 kr

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Epigenetics and Regeneration compiles the first foundational reference on epigenetic mechanisms governing tissue development, repair, homeostasis, and regeneration, as well as pathways to employ these mechanisms in clinical practice and translational science. In this book, life science researchers, clinicians, and students will discover an interdisciplinary resource bringing together common themes in the field, background overviews, research methods, recent advances, and opportunities for drug discovery. Throughout this volume, special attention is paid to pre-clinical and first clinical studies aimed at increasing the regenerative potential of damaged tissues by epigenetic drugs, as well as innovative, discipline spanning strategies to enhance cell reprogramming.

As an all-inclusive, evidence-based volume, Epigenetics and Regeneration will stimulate discussion and boost new research in this fascinating and impactful area of translational epigenetics.

Provides a foundational overview of epigenetics in regenerative medicine
Examines epigenetic components of tissue regeneration for a variety of organ systems and tissue types, as well as current attempts to employ these mechanisms in clinical practice
Offers researchers, students, clinicians, and pharmacologists the tools they need to enhance tissue development, repair, homeostasis, and regeneration and explore new epigenetic therapeutic pathways
Features chapter contributions from leading international researchers and clinicians in the fields of epigenetics and regenerative medicine

Produktinformation

Utgivningsdatum2019-05-25
Mått191 x 235 x 30 mm
Vikt1 040 g
FormatInbunden
SpråkEngelska
SerieTranslational Epigenetics
Antal sidor541
FörlagElsevier Science
MedarbetareDaniela Palacios
ISBN9780128148792

Tillhör följande kategorier

Biovetenskap inom Naturvetenskap och teknik

Dr. Daniela Palacios, PhD, is the director of the Epigenetics and Signal Transduction Laboratory at Fondazione Santa Lucia in Rome, Italy. She was trained as a molecular biologist in top academic and health institutions located in four different countries (Spain, UK, Italy, and USA). Research in her laboratory integrates state-of-the-art genomic and proteomic approaches with biochemistry, imaging, and novel RNA-based nanotechnologies to study how environmental stimuli modulate the epigenome during tissue regeneration and oncogenic transformation. The goal of the laboratory is to integrate basic research with innovative technological approaches to develop new tools for biomedical applications.Dr. Palacios has authored over 20 peer-reviewed articles and reviews on the subjects of epigenetics, development, and regeneration, including a chapter in Medical Epigenetics. In the past, she has participated as editor and guest editor to several journals within the fields of development and genomics.

1. Epigenetics and Regeneration: An OverviewSection I: Epigenetics: molecular players and mechanisms2. Dynamics and mechanisms of DNA methylation reprogramming3. Histone modifications4. Non-coding RNAs as Regulators of Gene Expression in Pluripotency and Differentiation5. Organizing Principles for the Spatial Folding of ChromosomesSection II: Development, Reprogramming & Tissue regeneration6. Epigenetics of early mammalian development: A Pathway to Regenerative Medicine7. Somatic Cell Epigenetic Reprogramming: Molecular Mechanisms and Therapeutic Potential8. Regenerative potential across species: An Eco-Evo-Devo PerspectiveSection III: Regenerative medicine: The epigenetics of tissue homeostasis, repair and regeneration9. Common challenges in tissue regeneration10. Epigenetic Mechanisms in Liver and Pancreas Generation and Regeneration11. Transcriptional and Epigenetic Mechanisms Controlling Intestinal Cell Fate 12. Using Epigenetics as a Pharmacological Tool in Heart Regeneration13. Epigenetic Regulation of Muscle Stem Cells During Skeletal Muscle Regeneration and Disease14. The Intrinsic Role of Epigenetics in Axonal Regeneration 15. Insights Into the Epigenetics of Retinal Development and Diseases16. At the Intersection of Epigenetics and Regeneration: An Analysis of the Experimental Outlook of Organoid TechnologySection IV: Epigenetics, regeneration and environment17. Epigenetic pharmacology in regenerative medicine (epi-drugs) 18. Genomic and Epigenomic Potential With Age: Genome, Epigenome, and the Epigenetic Clock19. Epigenetics and Lifestyle: The Impact of Stress, Diet, and Social Habits on Tissue Homeostasis20. Section V: Conclusive Remarks 20. iPSC- and Organoid-Based Biomedicine at the Intersection of Epigenetics and Regeneration: Charting the Normative Contours of Emerging Biomedical Platforms