John D. Aplin, Asgerally T Fazleabas, Stanley R Glasser, Linda C. Giudice

• List of Contributors. Preface to the First Edition. Preface to the Second Edition. Color Plates. Section I: Development. 1. Embryology of the Uterus. 2. Puberty, Menarche and the Endometrium. Section II: Mature Female Reproductive Tract. 3. Menstrual and Estrous Cycles. 4. The Fine Structure of the Mature Human Endometrium. 5. The Cytoskeleton of Uterine Epithelial and Stromal Cells. 6. Endometrial Angiogenesis, Arteriogenesis, and Lymphangiogenesis. 7. Endometrial Imaging. 8. Estrogen and Progesterone Regulation of Cell Proliferation in the Endometrium of Muridae and Humans. 9. Progesterone Antagonists and the Non-Human Primate Endometrium. Section III: Regulatory Biology. 10. Endometrial Stem Cells. 11. Transgenic Models of Uterine Biology. 12. Estrogen-Regulated Genes in the Endometrium. 13. Progesterone-Regulated Genes in the Endometrium. 14. Transcriptomics. 15. Paracrine Mediators of Endometrial Growth and Differentiation. 16. A Comparative View of Prostaglandin Action in the Uterus. Section IV: Establishment of Pregnancy. 17. Maternal Recognition of Pregnancy. 18. Chorionic Gonadotropin Signaling at the Maternal–Fetal Interface. 19. Embryo–Endometrial Signaling. 20. Endometrial Receptivity. 21. Connexins: Indicators for Hormonal and Blastocyst-Mediated Endometrial Differentiation. 22. Blastocyst Implantation: The Adhesion Cascade. 23. The Prolactin Family: Regulators of Uterine Biology. Section V: The Endometrial Stroma. 24. Endometrial Extracellular Matrix. 25. Signaling and Transcription Factor Networks in the Human Endometrial Stroma. 26. Human Endometrial Hemostasis During the Menstrual Cycle and Gestation. 27. Uterine Stromal Cell Differentiation in Non-Decidualizing Species. Section VI: Placentation. 28a. Implantation of the Blastocyst: I. Comparative Studies. 28b. Implantation of the Blastocyst: II. Implantation in Primates. 29. Human Placental Development. 30. Differentiation of the Invasive Cytotrophoblast Lineage in Normal Pregnancy and in Preeclampsia. 31. Mechanisms of Trophoblast Differentiation and Maternal–Fetal Interactions in the Mouse. 32. Epitheliochorial and Endotheliochorial Placentas. Section VII: Immunobiology. 33. Innate and Adaptive Immunity in the Human Female Reproductive Tract: Influence of the Menstrual Cycle and Menopause on the Mucosal Immune System in the Uterus. 34. Molecular Immunology of the Maternal–Fetal Interface. 35. Cytokine and Chemokine Regulation of Endometrial Immunobiology. 36. Endometrial Complement: Physiology and Pathophysiology. Section VIII: Pharmacological Models and Gene Therapy. 37. Endometrial Paradigms. 38. Endometrial Effects of Hormonal Contraception. 39. Endometrial Effects of Selective Progesterone Receptor Modulators. 40. In-Utero Gene Transfer: Promises and Problems. Section IX: Assisted Reproductive Technology. 41. Gamete Quality and Assisted Reproductive Technologies. 42. Unanswered Questions and Proposed Solutions in Assisted Reproductive Technologies. 43. Clinical Relevance of Endometrial Assessment. 44. Reproductive Freedom and Access to Assisted Reproductive Technologies. Section X: Pathology and Therapy. 45. The Endometrium of Polycystic Ovary Syndrome. 46. Endometriosis. 47. The Pathophysiology of Dysfunctional Uterine Bleeding. 48. Colonization and Infection of the Endometrium. 49. Ectopic Pregnancy. 50. Preeclampsia and Intrauterine Growth Restriction. 51. Aging of the Endometrium. 52. The Effects of Hormone Therapy and Botanicals and Dietary Supplements on the Endometrium. 53. Uterine Disease in Midlife and Beyond: The Menopausal Transition and Postmenopause. 54. Benign Uterine Disease: Leiomyomata and Benign Polyps. 55. Models of Endometrial Carcinogenesis. 56. Malignancy.

"an impressive international list of authoritative authors who are leaders in their respective fields ... a unique reference tool for students and investigators"- Journal of Fertility & Sterility, about the previous edition

John D. Aplin, Asgerally T Fazleabas, Stanley R Glasser, Linda C. Giudice

• List of Contributors. Preface to the First Edition. Preface to the Second Edition. Color Plates. Section I: Development. 1. Embryology of the Uterus. 2. Puberty, Menarche and the Endometrium. Section II: Mature Female Reproductive Tract. 3. Menstrual and Estrous Cycles. 4. The Fine Structure of the Mature Human Endometrium. 5. The Cytoskeleton of Uterine Epithelial and Stromal Cells. 6. Endometrial Angiogenesis, Arteriogenesis, and Lymphangiogenesis. 7. Endometrial Imaging. 8. Estrogen and Progesterone Regulation of Cell Proliferation in the Endometrium of Muridae and Humans. 9. Progesterone Antagonists and the Non-Human Primate Endometrium. Section III: Regulatory Biology. 10. Endometrial Stem Cells. 11. Transgenic Models of Uterine Biology. 12. Estrogen-Regulated Genes in the Endometrium. 13. Progesterone-Regulated Genes in the Endometrium. 14. Transcriptomics. 15. Paracrine Mediators of Endometrial Growth and Differentiation. 16. A Comparative View of Prostaglandin Action in the Uterus. Section IV: Establishment of Pregnancy. 17. Maternal Recognition of Pregnancy. 18. Chorionic Gonadotropin Signaling at the Maternal–Fetal Interface. 19. Embryo–Endometrial Signaling. 20. Endometrial Receptivity. 21. Connexins: Indicators for Hormonal and Blastocyst-Mediated Endometrial Differentiation. 22. Blastocyst Implantation: The Adhesion Cascade. 23. The Prolactin Family: Regulators of Uterine Biology. Section V: The Endometrial Stroma. 24. Endometrial Extracellular Matrix. 25. Signaling and Transcription Factor Networks in the Human Endometrial Stroma. 26. Human Endometrial Hemostasis During the Menstrual Cycle and Gestation. 27. Uterine Stromal Cell Differentiation in Non-Decidualizing Species. Section VI: Placentation. 28a. Implantation of the Blastocyst: I. Comparative Studies. 28b. Implantation of the Blastocyst: II. Implantation in Primates. 29. Human Placental Development. 30. Differentiation of the Invasive Cytotrophoblast Lineage in Normal Pregnancy and in Preeclampsia. 31. Mechanisms of Trophoblast Differentiation and Maternal–Fetal Interactions in the Mouse. 32. Epitheliochorial and Endotheliochorial Placentas. Section VII: Immunobiology. 33. Innate and Adaptive Immunity in the Human Female Reproductive Tract: Influence of the Menstrual Cycle and Menopause on the Mucosal Immune System in the Uterus. 34. Molecular Immunology of the Maternal–Fetal Interface. 35. Cytokine and Chemokine Regulation of Endometrial Immunobiology. 36. Endometrial Complement: Physiology and Pathophysiology. Section VIII: Pharmacological Models and Gene Therapy. 37. Endometrial Paradigms. 38. Endometrial Effects of Hormonal Contraception. 39. Endometrial Effects of Selective Progesterone Receptor Modulators. 40. In-Utero Gene Transfer: Promises and Problems. Section IX: Assisted Reproductive Technology. 41. Gamete Quality and Assisted Reproductive Technologies. 42. Unanswered Questions and Proposed Solutions in Assisted Reproductive Technologies. 43. Clinical Relevance of Endometrial Assessment. 44. Reproductive Freedom and Access to Assisted Reproductive Technologies. Section X: Pathology and Therapy. 45. The Endometrium of Polycystic Ovary Syndrome. 46. Endometriosis. 47. The Pathophysiology of Dysfunctional Uterine Bleeding. 48. Colonization and Infection of the Endometrium. 49. Ectopic Pregnancy. 50. Preeclampsia and Intrauterine Growth Restriction. 51. Aging of the Endometrium. 52. The Effects of Hormone Therapy and Botanicals and Dietary Supplements on the Endometrium. 53. Uterine Disease in Midlife and Beyond: The Menopausal Transition and Postmenopause. 54. Benign Uterine Disease: Leiomyomata and Benign Polyps. 55. Models of Endometrial Carcinogenesis. 56. Malignancy.

"an impressive international list of authoritative authors who are leaders in their respective fields ... a unique reference tool for students and investigators"- Journal of Fertility & Sterility, about the previous edition

John D. Aplin, Asgerally T Fazleabas, Stanley R Glasser, Linda C. Giudice

• List of Contributors. Preface to the First Edition. Preface to the Second Edition. Color Plates. Section I: Development. 1. Embryology of the Uterus. 2. Puberty, Menarche and the Endometrium. Section II: Mature Female Reproductive Tract. 3. Menstrual and Estrous Cycles. 4. The Fine Structure of the Mature Human Endometrium. 5. The Cytoskeleton of Uterine Epithelial and Stromal Cells. 6. Endometrial Angiogenesis, Arteriogenesis, and Lymphangiogenesis. 7. Endometrial Imaging. 8. Estrogen and Progesterone Regulation of Cell Proliferation in the Endometrium of Muridae and Humans. 9. Progesterone Antagonists and the Non-Human Primate Endometrium. Section III: Regulatory Biology. 10. Endometrial Stem Cells. 11. Transgenic Models of Uterine Biology. 12. Estrogen-Regulated Genes in the Endometrium. 13. Progesterone-Regulated Genes in the Endometrium. 14. Transcriptomics. 15. Paracrine Mediators of Endometrial Growth and Differentiation. 16. A Comparative View of Prostaglandin Action in the Uterus. Section IV: Establishment of Pregnancy. 17. Maternal Recognition of Pregnancy. 18. Chorionic Gonadotropin Signaling at the Maternal–Fetal Interface. 19. Embryo–Endometrial Signaling. 20. Endometrial Receptivity. 21. Connexins: Indicators for Hormonal and Blastocyst-Mediated Endometrial Differentiation. 22. Blastocyst Implantation: The Adhesion Cascade. 23. The Prolactin Family: Regulators of Uterine Biology. Section V: The Endometrial Stroma. 24. Endometrial Extracellular Matrix. 25. Signaling and Transcription Factor Networks in the Human Endometrial Stroma. 26. Human Endometrial Hemostasis During the Menstrual Cycle and Gestation. 27. Uterine Stromal Cell Differentiation in Non-Decidualizing Species. Section VI: Placentation. 28a. Implantation of the Blastocyst: I. Comparative Studies. 28b. Implantation of the Blastocyst: II. Implantation in Primates. 29. Human Placental Development. 30. Differentiation of the Invasive Cytotrophoblast Lineage in Normal Pregnancy and in Preeclampsia. 31. Mechanisms of Trophoblast Differentiation and Maternal–Fetal Interactions in the Mouse. 32. Epitheliochorial and Endotheliochorial Placentas. Section VII: Immunobiology. 33. Innate and Adaptive Immunity in the Human Female Reproductive Tract: Influence of the Menstrual Cycle and Menopause on the Mucosal Immune System in the Uterus. 34. Molecular Immunology of the Maternal–Fetal Interface. 35. Cytokine and Chemokine Regulation of Endometrial Immunobiology. 36. Endometrial Complement: Physiology and Pathophysiology. Section VIII: Pharmacological Models and Gene Therapy. 37. Endometrial Paradigms. 38. Endometrial Effects of Hormonal Contraception. 39. Endometrial Effects of Selective Progesterone Receptor Modulators. 40. In-Utero Gene Transfer: Promises and Problems. Section IX: Assisted Reproductive Technology. 41. Gamete Quality and Assisted Reproductive Technologies. 42. Unanswered Questions and Proposed Solutions in Assisted Reproductive Technologies. 43. Clinical Relevance of Endometrial Assessment. 44. Reproductive Freedom and Access to Assisted Reproductive Technologies. Section X: Pathology and Therapy. 45. The Endometrium of Polycystic Ovary Syndrome. 46. Endometriosis. 47. The Pathophysiology of Dysfunctional Uterine Bleeding. 48. Colonization and Infection of the Endometrium. 49. Ectopic Pregnancy. 50. Preeclampsia and Intrauterine Growth Restriction. 51. Aging of the Endometrium. 52. The Effects of Hormone Therapy and Botanicals and Dietary Supplements on the Endometrium. 53. Uterine Disease in Midlife and Beyond: The Menopausal Transition and Postmenopause. 54. Benign Uterine Disease: Leiomyomata and Benign Polyps. 55. Models of Endometrial Carcinogenesis. 56. Malignancy.

"an impressive international list of authoritative authors who are leaders in their respective fields ... a unique reference tool for students and investigators"- Journal of Fertility & Sterility, about the previous edition