Linda C. Giudice, MD, PhD, University of California, San Francisco, CA, USA Hans L. H. Evers, MD, PhD, University of Maastricht, NetherlandsDavid Healy, MB BS, PhD, Monash University, Melbourne, Australia

• List of Contributors, viiiPreface, xiiiList of Abbreviations, xvPart 1: History, Epidemiology, and Economics1 History of Endometriosis: A 20th-Century Disease, 3Ivo Brosens and Giuseppe Benagiano2 Endometriosis: Epidemiology, and Etiological Factors, 19Fabio Parazzini, Paolo Vercellini and Claudio Pelucchi3 Economic Perspective on Diagnosis and Treatment of Endometriosis, 27Steven Simoens and Thomas M. D’HooghePart 2: Pathogenesis4 Pathogenesis: Development of the Female Genital Tract, 35Jolande A. Land and Johannes L.H. Evers5 Theories on the Pathogenesis of Endometriosis, 42Annemiek W. Nap6 Understanding the Pathogenesis of Endometriosis: Gene Mapping Studies, 54Jodie N. Painter, Krina T. Zondervan and Grant W. Montgomery7 Pathogenesis: Epigenetics, 65Sun-Wei GuoPart 3: Disease Characterization8 Endometriosis: Disease Classification and Behavior, 81G. David Adamson9 Peritoneal, Ovarian, and Rectovaginal Endometriosis are Three Different Entities, 92Jacques Donnez, Olivier Donnez, Jean-Christophe Lousse and Jean Squifflet10 Extra-abdominal Endometriosis, 108Antonio Bobbio, Diane Damotte, Anne Gompel and Marco AlifanoPart 4: Biological Basis and Pathophysiology of Endometriosis11 Biology of Eutopic and Ectopic Endometrium in Women with Endometriosis, 117Petra A. B. Klemmt and Anna Starzinski-Powitz12 Stem Cells in Endometriosis, 130Caroline E. Gargett, Hirotaka Masuda and Gareth C. Weston13 Role of Steroid Hormones: Estrogen and Endometriosis, 140Elke Winterhager14 Role of Steroid Hormones: Progesterone Signaling, 145Shirin Khanjani, Marwa K. Al-Sabbagh, Luca Fusi and Jan J. Brosens15 Early Origins of Endometriosis: Role of Endocrine Disrupting Chemicals, 153Germaine M. Buck Louis16 Signaling Pathways in Endometriosis (Eutopic/Ectopic), 164J. Julie Kim and Xunqin Yin17 MicroRNAs in Endometriosis, 173M. Louise Hull and Cristin G. Print18 HOX Genes and Endometriosis, 184Jennifer L. Kulp, Hakan Cakmak and Hugh S. Taylor19 Angiogenesis and Endometriosis, 190Patrick. G. Groothuis20 Uterine Peristalsis and the Development of Endometriosis and Adenomyosis, 200Gerhard Leyendecker and Ludwig Wildt21 Pelvic Mechanisms Involved in the Pathophysiology of Pain in Endometriosis, 212Ian S. Fraser, Natsuko Tokushige, Alison J. Hey-Cunningham, Marina Berbic and Cecilia H. M. Ng22 Neuroendocrine Aspects of Endometriosis-Associated Pain, 230Pamela Stratton and Karen J. Berkley23 Pathophysiology of Infertility in Endometriosis, 240Bruce A. Lessey and Steven L. Young24 Inflammation and Endometriosis, 255Daniela Hornung and Ursula von WussowPart 5: Models of Endometriosis25 Models of Endometriosis: In vitro and In vivo Models, 265Ruth Grümmer26 Models of Endometriosis: Animal Models I – Rodent-based Chimeric Models, 270Kaylon L. Bruner-Tran, Melinda E. McConaha and Kevin G. Osteen27 Models of Endometriosis: Animal Models II – Non-human Primates, 285Asgerally T. FazleabasPart 6: Diagnosis of Endometriosis28 Surgical Historical Overview, 295Ayman Al-Talib and Togas Tulandi29 Diagnosis of Endometriosis: Imaging, 299Gerard A. J. Dunselman and Regina G. H. Beets-Tan30 Diagnosis of Endometriosis: Biomarkers, 309Beata E. Seeber and Kurt T. Barnhart31 Diagnosis of Endometriosis: Proteomics, 324Andrew N. Stephens, Luk J. F. Rombauts and Lois A. Salamonsen32 Diagnosis of Endometriosis: Transcriptomics, 336Richard O. Burney and Linda C. GiudicePart 8: Surgical Therapies for Pain37 Surgical Therapies: Principles and Triage in Endometriosis, 387Alan Lam, Tommaso Bignardi and Su-Yen Khong38 Surgical Therapies: Peritoneal Endometriosis Surgery, 396Michael P. Diamond and Valerie I. Shavell39 Surgical Therapies: Pouch of Douglas and Uterovaginal Pouch Resection for Endometriosis, 402Maurício S. Abrão, Sérgio Podgaec and Luiz Flávio Cordeiro Fernandes40 Surgical Therapies: Randomized Controlled Trials in Endometriosis, 410Jason Abbott41 Surgical Therapies: Rectal/Bowel Endometriosis, 419Jim Tsaltas42 Surgical Therapies: Ureteric Dissection and Urological Endometriosis, 426Anna Rosamilia and Caroline Dowling43 Surgical Therapies: Robotics and Endometriosis, 438Camran Nezhat, Arathi Veeraswamy and Chandhana PakaPart 9: Infertility and Endometriosis44 Medical Therapy of Endometriosis: Subfertility, 449Johannes L. H. Evers45 Infertility Therapies: The Role of Surgery, 455Oswald Petrucco and David L. Healy46 Infertility Therapies: The Role of Assisted Reproductive Technologies, 462Kimberly Moon, Jeris Cox and Alan DeCherney47 Ovarian Endometrioma: Surgery and Fertility Preservation, 473Luk J. F. RombautsPart 7: Medical Therapies for Pain33 Medical Therapies: Randomized Controlled Trials/ Traditional Medical Therapies, 343Neil P. Johnson34 Medical Therapies: Progestins, 351Andrew Horne and Hilary O. D. Critchley35 Medical Therapies: Aromatase Inhibitors, 357Serdar E. Bulun, Erkut Attar, Bilgin Gurates, You-Hong Chen, Hideki Tokunaga, Diana Monsivais and Mary Ellen Pavone36 Medical Therapies: Statins, 366Anna Sokalska and Antoni J. DulebaPart 10: Associated Disorders48 Endometriosis and Autoimmunity, 485Srinu Pathivada and Thomas D’Hooghe49 Endometriosis and Cancer: Epidemiology, 501Paola Viganò, Edgardo Somigliana, Fabio Parazzini and Paolo Vercellini50 Molecular Mechanisms Underlying Endometriosis and Endometriosis-Related Cancers, 512Daniela Dinulescu51 Pregnancy and Obstetric Outcomes in Women with Endometriosis, 519Henrik Falconer52 Sexuality in Endometriosis, 524Brigitte Leeners53 Psychosomatic Aspects, 533Brigitte Leeners54 Endometriosis in the Adolescent Patient, 548Claire Templeman55 Fertility Preservation in Patients with Endometrioma, 555Jennifer Hirshfeld-Cytron, Candace Tingen and Teresa K. Woodruff56 Eye to the Future: Research, Diagnostics, and Therapeutics, 560Peter A.W. Rogers and Gareth C. WestonIndex, 565The color plate section can be found facing p. 78

“The stellar cast of contributors, led by world-leading editors from the US, Europe, and Asia-Pacific, have produced a contemporary tour-de-force that should be on the bookshelf of anyone who provides medical care for women.”  (The Journal of Obstetrics and Gynecology of India, 1 May 2014)“This book is an excellent resource for trainees who want to further their knowledge of endometriosis as well as senior doctors who want to keep up-to-date with recent advances in diagnosis and management of endometriosis.”  (The Obstetrician & Gynaecologist, 1 October 2013)“It provides a comprehensive approach to the biology, diagnosis, and treatment of endometriosis, showcasing the latest in molecular, genetic, and epigenetic research underlying the pathophysiology of endometriosis.  It is a must read for every single person who is serious about moving the field of endometriosis forward.”   (Endometriosis.org, 2012)