John A. Thomas Vice President for Academic Services, Professor of Pharmacology, Department of Academic Service University of Texas Health Science Center, San Antonio, Texas. Howard D. Colby, Ph.D. Professor, Department of Pharmacology and Toxicology Philadelphia College of Pharmacy and Science, Philadelphia, Pennsylvania.

• Preface Introduction 1. Chemically-Induced Injury of the Parathyroid Gland: Pathophysiology and Mechanistic Considerations 2. Physiology of the Thyroid Gland and Agents Affecting Its Secretion 3. Chemically-Induced Changes in the Thyroid 4. Toxicology of the Adrenal Cortex: Role o f Metabolic Activation 5. Chemically-Induced Lesions in the Adrenal Cortex 7. Xenoestrogens and Estrogen Receptor Action 8. Cellular and Molecular Effects of Androgenic-Anabolic Steroids 9. Role of Cadmium in the Etiology of Cancer of the Prostate10. Actions of Chemicals and Other Factors on Ley dig Cell Growth and Proliferation 11. Toxic Effects of Cyproheptadine and Its Analogs in Insulin-Producing Cells 12. Epidemiologic Evidence for Toxic Effects of Occupational and Environmental Chemicals on the Testes

John A. Thomas Vice President for Academic Services, Professor of Pharmacology, Department of Academic Service University of Texas Health Science Center, San Antonio, Texas. Howard D. Colby, Ph.D. Professor, Department of Pharmacology and Toxicology Philadelphia College of Pharmacy and Science, Philadelphia, Pennsylvania.

• Preface Introduction 1. Chemically-Induced Injury of the Parathyroid Gland: Pathophysiology and Mechanistic Considerations 2. Physiology of the Thyroid Gland and Agents Affecting Its Secretion 3. Chemically-Induced Changes in the Thyroid 4. Toxicology of the Adrenal Cortex: Role o f Metabolic Activation 5. Chemically-Induced Lesions in the Adrenal Cortex 7. Xenoestrogens and Estrogen Receptor Action 8. Cellular and Molecular Effects of Androgenic-Anabolic Steroids 9. Role of Cadmium in the Etiology of Cancer of the Prostate10. Actions of Chemicals and Other Factors on Ley dig Cell Growth and Proliferation 11. Toxic Effects of Cyproheptadine and Its Analogs in Insulin-Producing Cells 12. Epidemiologic Evidence for Toxic Effects of Occupational and Environmental Chemicals on the Testes

John A. Thomas Vice President for Academic Services, Professor of Pharmacology, Department of Academic Service University of Texas Health Science Center, San Antonio, Texas. Howard D. Colby, Ph.D. Professor, Department of Pharmacology and Toxicology Philadelphia College of Pharmacy and Science, Philadelphia, Pennsylvania.

• Preface Introduction 1. Chemically-Induced Injury of the Parathyroid Gland: Pathophysiology and Mechanistic Considerations 2. Physiology of the Thyroid Gland and Agents Affecting Its Secretion 3. Chemically-Induced Changes in the Thyroid 4. Toxicology of the Adrenal Cortex: Role o f Metabolic Activation 5. Chemically-Induced Lesions in the Adrenal Cortex 7. Xenoestrogens and Estrogen Receptor Action 8. Cellular and Molecular Effects of Androgenic-Anabolic Steroids 9. Role of Cadmium in the Etiology of Cancer of the Prostate10. Actions of Chemicals and Other Factors on Ley dig Cell Growth and Proliferation 11. Toxic Effects of Cyproheptadine and Its Analogs in Insulin-Producing Cells 12. Epidemiologic Evidence for Toxic Effects of Occupational and Environmental Chemicals on the Testes