Encyclopedia of Drug Metabolism and Interactions, Clinical Aspects

ALEXANDER V. LYUBIMOV, MD, PhD, DABT, is Director of the Toxicology Research Laboratory and Associate Professor of Pharmacology at the University of Illinois at Chicago. He has more than thirty years of experience in the fields of toxicology, bioanalytical chemistry, and drug efficacy. He has presented his research results at more than fifty national and international scientific conferences. In addition, he has published more than 140 scientific publications in peer-reviewed journals, books, and conference proceedings. Dr. Lyubimov has served as chair or president of several international conferences, including "Frontiers of Pharmacology and Toxicology," which he also organized.

• Contributors ixPreface to the Encyclopedia xxiiiPreface—Volume 6 xxviiPART X Clinical Aspects of Drug Metabolism and Interactions 11 Clinical Aspects of Drug Biotransformation: An Overview 3Michael D. Coleman and Louis L. Radulovic2 CYP450 Enzymes in Drug Discovery and Development: An Overview 53Lin Xu, Biplab Das, and Chandra Prakash3 DDI Risk Assessment and Evaluation in Pharmaceutical Development: Interfacing Drug Metabolism and Clinical Pharmacology 89Karthik Venkatakrishnan4 Current and Future Tools for Predicting Clinical Drug–Drug Interactions 151Peter L. Bullock and Olga V. Trubetskoy5 Predicting Human Biotransformation Pathways 177Shelby Anderson, Debra Luffer-Atlas, and Mary Pat Knadler6 Conjugation, Transport, and Elimination of Drugs in Humans 205Ronald E. Savage7 Role and Clinical Consequences of Human UDP-Glucuronosyltransferases 243Deepak K. Dalvie and Cho-Ming Loi8 Herb–Drug and Food–Drug Interactions 279Martin S. Lennard9 Effects of Liver Disease on Drug Metabolism in Humans 307Hui-Hui Tan and Thomas D. Schiano10 Role of Phase I Metabolism in Drug Activation and Clinical Treatment Outcomes 353Bernard Testa and André Pannatier11 Role of Metabolism in Toxicity of Drugs in Humans 377Amit S. Kalgutkar and Jonathan N. Bauman12 Idiosyncratic Drug Reactions and the Potential Role of Metabolism 403Jack P. UetrechtPART XI Metabolism of Specific Drug Groups and Patient Populations 45513 Metabolism of Psychotropic Drugs 457Julia Stingl, Jessica Oesterheld, and Miia Turpeinen14 Metabolism-Based Consequences of Polytherapy with Antiepileptic Drugs 473Philip N. Patsalos15 Oral Chemotherapeutic Agents 499Shin Ogita, Patricia LoRusso, and Jing Li16 Drug Metabolism and Interactions in Pediatric Patients 537Souzan Yanni and Karel Allegaert17 Population-Based Pharmacokinetic Modeling and Simulation 581Frédéric Y. Bois and Masoud Jamei18 Clinical Pharmacology in Drug Labeling. The Impact of Drug Metabolism and Clinical Pharmacology on Recommended Dose of Drugs 609Stuart DombeyIndex 621