Encyclopedia of Drug Metabolism and Interactions, 6 Volume Set

ALEXANDER V. LYUBIMOV, MD, PhD, DABT, is Director of the Toxicology Research Laboratory and Associate Professor of Pharmacology at the University of Illinois at Chicago. He has more than thirty years of experience in the fields of toxicology, bioanalytical chemistry, and drug efficacy. He has presented his research results at more than fifty national and international scientific conferences. In addition, he has published more than 140 scientific publications in peer-reviewed journals, books, and conference proceedings. Dr. Lyubimov has served as chair or president of several international conferences, including "Frontiers of Pharmacology and Toxicology," which he also organized.

• VOLUME IPart 1: Basics Overview of Drug MetabolismChapter 1 Review of Drug Metabolism in Drug Discovery and DevelopmentChapter 2 Reactions and Models of Drug MetabolismChapter 3 Enzyme kinetics of drug metabolism reactions and drug-drug interactionsChapter 4 Developmental changes in drug metabolizing enzymesChapter 5 Species differences in drug metabolizing enzymesPart II: Enzyme systems involved in drug metabolism and interactions in animals and humansChapter 6 Structure and function of cytochrome P450 enzymesChapter 7 Mechanism of cytochrome P450 mediated reactionsChapter 8 Transcriptional regulation of cytochrome P450 enzymesChapter 9 Cytochrome P450 polymorphismsChapter 10 Flavin monooxygenaseChapter 11 Molybdenum containing enzymesChapter 12 Amine odidases and reductasesChapter 13 Epoxide hydrolaseChapter 14 Esterases and amidasesChapter 15 UDP- glucuronosyltransferasesChapter 16 SulfotransferasesChapter 17 Glutathione S- transferasesChapter 18 Amino acid conjugationVOLUME IIPart III: General principals of ADME. Drug transporters and other mechanisms of transportChapter 1 Introduction to ADME. OverviewChapter 2 Anatomical and Physiological Parameters that Influence Gastrointestinal AbsorptionChapter 3 Absorption of drugs into the bodyChapter 4 General principles of drug distributionChapter 5 ABC drug transporters and their impact on drug disposition/drug sensitivity and resistanceChapter 6 SLC family transportersChapter 7 General principles of drug metabolismChapter 8 Systems where drug metabolism occursChapter 9 Mass balance studies in animals and humansChapter 10 Bioavailability and bioequivalenceChapter 11 Allometric scalingChapter 12 Effect of protein binding in ADMEChapter 13 Excretion systemsChapter 14 Pharmacokinetics (PK) and toxicokinetics (TK)Chapter 15 Experimental design/mathematical models and data analysis/interpretation for PK /TK studiesChapter 16 Physiologically-Based Pharmacokinetic ModelingChapter 17 PharmacodynamicsChapter 18 Interrelationships between Pharmacokinetics / Pharmacodynamics and metabolismPart IV: ADME of some specific groups of drugs and delivery systemsChapter 19 ADME of herbal and dietary constituentsChapter 20 ADME of anticancer drugsChapter 21 ADME of cardiovascular drugsChapter 22 ADME of biological drugsChapter 23 ADME of natural toxinsChapter 24 Metabolism and drug-drug interactions in pregnant mother/placenta/fetusVOLUME IIIPart V: Drug Design and developmentChapter 1 Where and when does drug metabolism enter as a concern?Chapter 2 Challenges in frontloading toxicity testing of anti- cancer drugs in drug discoveryChapter 3 Role of ADME for selection of new drug candidatesChapter 4 Efficient drug development. How to speed up the development processChapter 5 Metabolite profiling and identificationChapter 6 Bioactivation and oxidative stressChapter 7 Metabolism in drug safety evaluationPart VI: Methods and protocols for prediction and evaluation of drug metabolism and drug interaction studiesChapter 8 In silico models of drug metabolism and drug interactionsChapter 9 Methods for determination of enzyme kinetics and metabolic ratesChapter 10 Assays and microarrays for metabolic pathwaysChapter 11 Applications using Caco-2 cells and TC7 cells for drug metabolism studiesChapter 12 In vitro liver systems to study induction/inhibition. Prediction of in vivo metabolism and drug-drug interactionsChapter 13 Assessing the Hepatic Disposition and Toxicity of Xenobiotics Using Primary HepatocytesChapter 14 Monoclonal Antibody Based Analyses of Human Drug Metabolism and Multifuctional Cytochromes P450Chapter 15 Validation of precision- cut slices as a tool to study induction of drug metabolismChapter 16 Practical aspects of high throughput solubility and dissolution assessment in preformulationChapter 17 Integrated Approaches to Blood Brain Barrier and its role for drug metabolism and interactionsChapter 18 In vivo models (not genetically modified)Chapter 19 Using mouse knockout and transgenic models to study metabolismVOLUME IVPart VII: Pharmacology and toxicologyChapter 1 Introduction. Overview. Role of metabolism in drug toxicityChapter 2 Bioactivation I: Phase I (P450)Chapter 3 Bioactivation II: Phase I (non P450)Chapter 4 Bioactivation III: Phase IIChapter 5 Covalent BindingChapter 6 MISTChapter 7 Cell- based predictors for Toxicities of MetabolitesChapter 8 ToxicogenomicsChapter 9 MetabonomicsChapter 10 ProteomicsChapter 11 Stereoselectivity in drug metabolismPART VIII: Influence of physiological conditions, diseases, drug- food interactions, age, sex, and other factors on drug metabolism and effectChapter 12 Genetic influence on metabolismChapter 13 Drug- Drug interactions 1: InhibitionChapter 14 Drug- Drug Interactions 2: InductionChapter 15 Ontogeny and MetabolismChapter 16 Natural Modulators of Human Drug Metabolism: Dietary supplements and their Clinical Relevance (Food Effects on Toxicity and Pharmacology)Chapter 17 Idiosyncratic drug interactionsChapter 18 Influence of inflammatory stress on drug (or xenobiotic) hepatotoxicityChapter 19 Regulation of Drug-Metabolizingnzymes and Transporters in Infection, Inflammation, and CancerVOLUME VPart IX: Bioanalytical methods of studying metabolismChapter 1 Introduction. Importance of in vivo/in vitro analytical results in drug development WalterChapter 2 General principles of mass spectrometry: LC-MS, LC-MS/MS, and GC-MSChapter 3 Electrospray and Infusion nanospray ionizationChapter 4 Emerging Atmospheric pressure ionizationChapter 5 Matrix assisted laser desorption ionization (MALDI)Chapter 6 Ion trap and quadrupole MSChapter 7 Hybrid LTQ- FTMS for Drug Metabolism ApplicationsChapter 8 Mass Spectrometry Imaging (MSI)Chapter 9 Ion Mobility Spectrometry and High Performance Tandem MS for metabolism studies and identificationChapter 10 Inductively coupled plasma mass spectrometry (ICP MS) for element- containing drug metabolism analysisChapter 11 Online Electrochemical LC- MS Techniques for ProfilingChapter 12 NMRChapter 13 Whole body autography and radioactive and non- radioactive isotope assaysChapter 14 Ligand binding assays (immunoassays)Chapter 16 Direct plasma analysis systemsChapter 17 Analytical method development and validation in accordance to the regulatory guidelinesChapter 18 Leveraging advances in HPLC to maximize DMPK data qualityChapter 19 Methodologies to Increase Analytical ThroughputChapter 20 Biomarkers to enable PK/PDChapter 21 Bioanalytics for Human MicrodosingChapter 22 Bioactivation and Reactive Metabolite AssaysChapter 23 Plasma protein bindingVOLUME VIPart X: Clinical aspects of drug metabolism and interactionsChapter 1 Overview and introduction. Role of drug metabolism and drug interactions in humansChapter 2 Human cytochrome P450 enzymesChapter 3 DDI Risk Assessment and Evaluation in Clinical Development: Interfacing Drug Metabolism and Clinical PharmacologyChapter 4 Current and future tools for predicting clinical drug interactionsChapter 5 Predicting human biotransformation pathwaysChapter 6 Conjugation, transport, and elimination of drugs in humansChapter 7 Role and clinical consequences of human UDP- GlucuronosyltransferasesChapter 8 Drug/food and drug/herb interactionsChapter 9 Effects of disease on metabolism of drugs in humansChapter 10 Role of Phase I metabolism in drug activation and clinical treatment outcomesChapter 11 Role of metabolism in toxicity of drugs in humansChapter 12 Idiosyncratic drug reactions and the potential role of metabolismPart XI Metabolism of specific drug groups and patient populationsChapter 13 Metabolism of psychotropic drugsChapter 14 Metabolic-based consequences of polytherapy with AEDChapter 15 Oral chemotherapeutic agents: Understanding mechanisms of action and drug interactionsChapter 16 Drug metabolism and interactions in pediatric patientsChapter 17 Population- based pharmacokinetic modeling and simulationChapter 18 Clinical Pharmacology in drug labeling. The impact of drug metabolism and clinical pharmacology on recommended dose of drugs

“This one-stop reference brings together information scattered throughout the literature, and it involved the efforts of 270 expert authors from 16 countries — a global endeavor accomplished under the leadership of editor Alexander Lyubimov (pharmacology, The U. of Illinois, Chicago).”  (Book News, 1 February 2013)"Summing Up: Recommended.  Graduate students through professionals/practitioners.”   (Choice, 1 March 2013)