Early Vascular Aging (EVA)

Michael Hecht Olsen is a professor in Hypertension and Cardiovascular Prevention at the Department for Regional Health Research, University of Southern Denmark, and senior consultant in cardiology at Department of Medicine 1, Holbaek Hospital, Denmark.Both clinically and in research, he works with hypertension, obesity, diabetes and cardiovascular risk stratification using measurements of subclinical cardiovascular damage (e.g., pulse wave analysis, ultrasound of the carotid arteries and echocardiography) and new biomarkers for deep phenotyping trying to develop individualized treatment. He has published over 200 publications (Web of Science H-index 47).Peter M. Nilsson is Senior Professor/expert in Clinical Cardiovascular Research at Lund University, Department of Clinical Sciences, Skåne University Hospital, Malmö, Sweden. For many years he has been developing the concept of EVA with numerous colleagues and the prevention of cardiovascular disease and type 2 diabetes.Stepane Laurent’s research interests are hypertension pathophysiology and management, pharmacology of antihypertensive drugs, arterial stiffness and vascular ageing. He has served as President of the European Society of Hypertension (ESH) (2007-2009) and President of the ARTERY Society (2010-2012), and is the author of over 500 referenced articles and 20 chapters in books.

• Chapter 1: Historical Aspects and Biology of AgingChapter 2: Cellular and Molecular Determinant of Arterial AgingChapter 3: Changing Demography of Europe-Greying PopulationsChapter 4: Population-Based StudiesChapter 5: Lessons from Amsterdam Growth and Health Longitudinal StudyChapter 6: History and Findings of the BLSAChapter 7: Changes in Peripheral Blood Pressure with Normal and Accelerated AgingChapter 8: Changes in Arterial Stiffness with Normal and Accelerated AgingChapter 9: Changes in Central Hemodynamics, Wave Reflection and Heart-Vessel Coupling with Normal and Accelerated AgingChapter 10: Early Aging of Endothelial Function and Platelet-Vessel Wall InteractionChapter 11: The Cross-Talk between the Macro and MicrocirculationChapter 12: Blood Pressure VariabilityChapter 13: Early Vascular Aging in Children with Low Birth Weight and/or PrematurityChapter 14: Age-Induced Endothelial Dysfunction and Intima-Media ThickeningChapter 15: Glucose Metabolism, Diabetes, and the Arterial WallChapter 16: Chronic Inflammation and AntherosclerosisChapter 17: Early and Late Stages of Chronic Kidney Disease in relation to Arterial ChangesChapter 18: Polycystic Ovarian SyndromeChapter 19: Early and Late Stages of Brain DamageChapter 20: Telomere Biology and Aging Chapter 21: Traditional versus new models of Risk PredictionChapter 22: Imaging Biomarkers: Aortic Stiffness and Carotid IMT as Predictors of CV DiseaseChapter 23: Genetic Markers in Prediction of CV DiseaseChapter 24: Vascular Aging and CV DiseaseChapter 25: Lifestyle Intervention: What works?Chapter 26: Targeting BP Lowering and Sympathetic Nervous SystemChapter 27: Targeting Central BP through the Macro-Microcirculation Cross-TalkChapter 28: Treatment of Abnormalities in Glucose and Lipid MetabolismChapter 29: New Drugs under Development for Cardiovascular PreventionChapter 30: Interventions to retard Biological Aging to be ExploredChapter 31: Immuniziation, Vaccines and Immunomodulation

"... it builds on the evidence in previous chapters, eventually signing off with a discussion of possible means to retard vascular aging...a good start on the expanding field of EVA. Score: 82 - 3 Stars" --Doody's