Early Phase Cancer Immunotherapy

Razelle Kurzrock, MD, is Senior Deputy Director for Clinical Science, Chief, Division of Hematology & Oncology, Murray Professor of Medicine, Director, Center for Personalized Cancer Therapy & Clinical Trials Office, University of California, San Diego. Sandip Patel, MD, is Assistant Professor, Cancer Immunotherapy Program, Experimental Therapeutics (Phase 1 Program), Thoracic Oncology, Division of Hematology & Oncology and Center for Personalized Cancer Therapy, UC San Diego Moores Cancer Center.

• Chapter 1 Primer on Cancer Immunotherapy and the Targeting of Native Proteins.- Chapter 2 Pharmacokinetics and Pharmacodynamics of Immunotherapy.- Chapter 3 Immunotherapeutic Biomarkers and Selection Strategies.- Chapter 4 Radiographic Evaluation of Immunotherapy.- Chapter 5 Cellular Therapy.- Chapter 6 Combinatorial Checkpoint Blockade Immunotherapy and Radiation.- Chapter 7 Early Phase Cancer Immunotherapy.- Chapter 8 Immune Checkpoint Combinations with Inflammatory Pathway Modulators.- Chapter 9 Combinations of Genomically and Immune-Targeted Therapies in Early-Phase Clinical Trials.- Chapter 10 Thoracic Immunotherapy.