Sarah E. Boslaugh, PhD, MPH, is a technical writer and editor as well as an adjunct faculty member of the Department of Biostatistics in the School of Public Health, Saint Louis University.

• Series ForewordAcknowledgmentsIntroductionSection I: Overview and Historical Background of Drug Resistance1 The Science of Drug ResistanceWhat Are Antimicrobials?Key Antibiotics in Medical HistoryWhat Is Antimicrobial Resistance?How Microbes Become ResistantWhy Drug Resistance Is a Concern2 The Role of Human Behavior in Drug ResistanceInappropriate Use of DrugsUse of Low-Quality DrugsUse of Antimicrobials in Animal Husbandry3 The Scope of the Problem TodayGlobal Overview of Drug ResistanceDrug Resistance in the United States4 Specific DiseasesTuberculosisGonorrheaMalariaHIVInfluenza5 Measures to Combat Drug ResistanceNational and International Standards of Prescribing PracticeInfection ControlVaccination ProgramsLimiting Disease Spread through TravelDeveloping New Antibiotics and Improved Diagnostic TestsSurveillance and Reporting ProgramsRecommendations for Global SurveillanceSection II: Contemporary Issues and Debates6 Drug Resistance as a National and International IssueStakeholdersRecommendations for Antibiotic UseDeveloping New Antibiotics7 Changing Physician and Pharmacist BehaviorDecision Making in MedicinePhysician and Pharmacist EducationHealth System Guidelines8 Changing Patient BehaviorPatient AdherenceObstacles to AdherenceInterventions to Improve Adherence9 Balancing Individual and Societal RightsBalancing Infection Control and the Right to Freedom and PrivacyDOTInvoluntary Quarantine10 Contributions of Research to the Fight Against Drug ResistanceThe Drug Development ProcessAntibiotics in the Drug Development Pipeline11 Antibiotics in Animal HusbandryHistorySpecific ThreatsThe Scope of the IssueBalancing Productivity and Public SafetySection III: ResourcesPrimary DocumentsCurrent ReportsAntimicrobial Resistance: Global Report on Surveillance: SummaryAntibiotic Resistance Threats in the United States, 2013: Executive SummaryAntimicrobial Resistance Surveillance in Europe, 2015: SummaryPolicy StatementsWHO Global Strategy for Containment of Antimicrobial Resistance: Executive SummaryNational Strategy for Combating Antibiotic Resistance Bacteria: Executive SummaryThe Judicious Use of Medically Important Antimicrobial Drugs in Food-Producing Animals: Executive SummaryTimelineSources for Further InformationGlossaryIndex

At each stage of the text, the reader is aware of the informational progress made—i.e., what information has come before and what information remains to complete the progression. The primary documents that serve as sources of information are identified and weighted. A helpful time line from 1632 to 2016 provides an unexpected historical background. Due to the overall superior quality of this work, it is most highly recommended for all readership levels. Summing Up: Highly recommended. All readers.

Sarah E. Boslaugh, PhD, MPH, is a technical writer and editor as well as an adjunct faculty member of the Department of Biostatistics in the School of Public Health, Saint Louis University.

• Series ForewordAcknowledgmentsIntroductionSection I: Overview and Historical Background of Drug Resistance1 The Science of Drug ResistanceWhat Are Antimicrobials?Key Antibiotics in Medical HistoryWhat Is Antimicrobial Resistance?How Microbes Become ResistantWhy Drug Resistance Is a Concern2 The Role of Human Behavior in Drug ResistanceInappropriate Use of DrugsUse of Low-Quality DrugsUse of Antimicrobials in Animal Husbandry3 The Scope of the Problem TodayGlobal Overview of Drug ResistanceDrug Resistance in the United States4 Specific DiseasesTuberculosisGonorrheaMalariaHIVInfluenza5 Measures to Combat Drug ResistanceNational and International Standards of Prescribing PracticeInfection ControlVaccination ProgramsLimiting Disease Spread through TravelDeveloping New Antibiotics and Improved Diagnostic TestsSurveillance and Reporting ProgramsRecommendations for Global SurveillanceSection II: Contemporary Issues and Debates6 Drug Resistance as a National and International IssueStakeholdersRecommendations for Antibiotic UseDeveloping New Antibiotics7 Changing Physician and Pharmacist BehaviorDecision Making in MedicinePhysician and Pharmacist EducationHealth System Guidelines8 Changing Patient BehaviorPatient AdherenceObstacles to AdherenceInterventions to Improve Adherence9 Balancing Individual and Societal RightsBalancing Infection Control and the Right to Freedom and PrivacyDOTInvoluntary Quarantine10 Contributions of Research to the Fight Against Drug ResistanceThe Drug Development ProcessAntibiotics in the Drug Development Pipeline11 Antibiotics in Animal HusbandryHistorySpecific ThreatsThe Scope of the IssueBalancing Productivity and Public SafetySection III: ResourcesPrimary DocumentsCurrent ReportsAntimicrobial Resistance: Global Report on Surveillance: SummaryAntibiotic Resistance Threats in the United States, 2013: Executive SummaryAntimicrobial Resistance Surveillance in Europe, 2015: SummaryPolicy StatementsWHO Global Strategy for Containment of Antimicrobial Resistance: Executive SummaryNational Strategy for Combating Antibiotic Resistance Bacteria: Executive SummaryThe Judicious Use of Medically Important Antimicrobial Drugs in Food-Producing Animals: Executive SummaryTimelineSources for Further InformationGlossaryIndex

At each stage of the text, the reader is aware of the informational progress made—i.e., what information has come before and what information remains to complete the progression. The primary documents that serve as sources of information are identified and weighted. A helpful time line from 1632 to 2016 provides an unexpected historical background. Due to the overall superior quality of this work, it is most highly recommended for all readership levels. Summing Up: Highly recommended. All readers.

Sarah E. Boslaugh, PhD, MPH, is a technical writer and editor as well as an adjunct faculty member of the Department of Biostatistics in the School of Public Health, Saint Louis University.

• Series ForewordAcknowledgmentsIntroductionSection I: Overview and Historical Background of Drug Resistance1 The Science of Drug ResistanceWhat Are Antimicrobials?Key Antibiotics in Medical HistoryWhat Is Antimicrobial Resistance?How Microbes Become ResistantWhy Drug Resistance Is a Concern2 The Role of Human Behavior in Drug ResistanceInappropriate Use of DrugsUse of Low-Quality DrugsUse of Antimicrobials in Animal Husbandry3 The Scope of the Problem TodayGlobal Overview of Drug ResistanceDrug Resistance in the United States4 Specific DiseasesTuberculosisGonorrheaMalariaHIVInfluenza5 Measures to Combat Drug ResistanceNational and International Standards of Prescribing PracticeInfection ControlVaccination ProgramsLimiting Disease Spread through TravelDeveloping New Antibiotics and Improved Diagnostic TestsSurveillance and Reporting ProgramsRecommendations for Global SurveillanceSection II: Contemporary Issues and Debates6 Drug Resistance as a National and International IssueStakeholdersRecommendations for Antibiotic UseDeveloping New Antibiotics7 Changing Physician and Pharmacist BehaviorDecision Making in MedicinePhysician and Pharmacist EducationHealth System Guidelines8 Changing Patient BehaviorPatient AdherenceObstacles to AdherenceInterventions to Improve Adherence9 Balancing Individual and Societal RightsBalancing Infection Control and the Right to Freedom and PrivacyDOTInvoluntary Quarantine10 Contributions of Research to the Fight Against Drug ResistanceThe Drug Development ProcessAntibiotics in the Drug Development Pipeline11 Antibiotics in Animal HusbandryHistorySpecific ThreatsThe Scope of the IssueBalancing Productivity and Public SafetySection III: ResourcesPrimary DocumentsCurrent ReportsAntimicrobial Resistance: Global Report on Surveillance: SummaryAntibiotic Resistance Threats in the United States, 2013: Executive SummaryAntimicrobial Resistance Surveillance in Europe, 2015: SummaryPolicy StatementsWHO Global Strategy for Containment of Antimicrobial Resistance: Executive SummaryNational Strategy for Combating Antibiotic Resistance Bacteria: Executive SummaryThe Judicious Use of Medically Important Antimicrobial Drugs in Food-Producing Animals: Executive SummaryTimelineSources for Further InformationGlossaryIndex

At each stage of the text, the reader is aware of the informational progress made—i.e., what information has come before and what information remains to complete the progression. The primary documents that serve as sources of information are identified and weighted. A helpful time line from 1632 to 2016 provides an unexpected historical background. Due to the overall superior quality of this work, it is most highly recommended for all readership levels. Summing Up: Highly recommended. All readers.