Drug Metabolism and Transport

Molecular Methods and Mechanisms

Inbunden, Engelska, 2004

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A compendium of proven experimental approaches and strategies for studying the bioactivation, detoxification, tissue distribution, and elimination of xenobiotics in the metabolism and/or transport of various chemicals. The authors address several of the major drug metabolizing systems, including the cytochrome P450 family, flavin-containing monooxygenases, glutathione, S-transferase, glucuronidation, N-acetylation, and sulfotransferases. Additional chapters present novel approaches to the study of: signaling pathways in the regulation of drug metabolism enzymes, how the modulation of thiols and other low molecular-weight cofactors can alter drug metabolism, and how modulation of drug metabolism pathways can influence antiviral therapy.

Produktinformation

Utgivningsdatum2004-09-24
Mått155 x 235 x 30 mm
Vikt789 g
FormatInbunden
SpråkEngelska
SerieMethods in Pharmacology and Toxicology
Antal sidor388
Upplaga2005
FörlagHumana Press Inc.
ISBN9781588293244

Tillhör följande kategorier

Farmakologi inom Medicin

Renal Cytochrome P450s and Flavin-Containing Monooxygenases.- Experimental Approaches for the Study of Cytochrome P450 Gene Regulation.- Insulin and Growth Factor Signaling.- Catalytic Function and Expression of Glutathione Transferase Zeta.- Glucuronidation of Fatty Acids and Prostaglandins by Human UDP-Glucuronosyltransferases.- Transcriptional Regulation of UDP-Glucuronosyltransferases.- Phenotypic and Genotypic Characterization of N-Acetylation.- Methods and Approaches to Study Metabolism and Toxicity of Acetaminophen.- Modulation of Drug Metabolism and Antiviral Therapies.- Modulation of Thiols and Other Low-Molecular-Weight Cofactors.- Multidrug Resistance Proteins and Hepatic Transport of Endo- and Xenobiotics.- Structural Determinants of Folate and Antifolate Membrane Transport by the Reduced Folate Carrier.- Glutathione Transport in the Kidneys.- Human Cytosolic Sulfotransferases.