Drug Discovery and Development, Third Edition

James J. O'Donnell, James T. O'Donnell

• Acknowledgments Introduction to the First Edition (1992) Introduction to the Second Edition (2006) Editors Contributors Chapter 1 Introduction to Drug Discovery and Development James J. O’Donnell III, John C. Somberg, and James T. O’Donnell SECTION I Overview Chapter 2 Current Opinions on the Trajectory of the Pharmaceutical Development John C. Somberg Chapter 3 Innovation in Drug Development: Perspectives of a Venture Capitalist Krishna Yeshwant SECTION II Drug Discovery Chapter 4 High-Throughput Screening Omar Perez, J. Pena, Virneliz Fernandez-Vega, Louis Scampavia, and Timothy Spicer Chapter 5 DNA-Encoded Compound Libraries: An Emerging Paradigm in Drug Hit Discovery Raphael M. Franzini Chapter 6 Bio-Targeted Nanomaterials for Theranostic Applications Sabyasachi Maiti and Kalyan Kumar Sen Chapter 7 The Development of Adoptive T-Cell Immunotherapies for Cancer: Challenges and Prospects David J. Dow, Steven J. Howe, Mala K. Talekar, and Laura A. Johnson Chapter 8 CRISPR in Drug Discovery Chih-Shia Lee and Ji Luo Chapter 9 Probiotics in the World: “Bugs-as-Drugs” Thomas Kuntz, Madeline Kim, Elle Simone Hill, Mariana C. Salas Garcia, and Jack A. Gilbert Chapter 10 Discovery and Early Development of the Next-Generation ALK Inhibitor, Lorlatinib (18): Agent for Non?Small-Cell Lung Cancer Paul F. Richardson SECTION III Drug Development Chapter 11 Integrated Drug Product Development: From Lead Candidate Selection to Life-Cycle Management Madhu Pudipeddi, Abu T.M. Serajuddin, Ankita V. S

This third edition, written by experts from around the world, is expected to be useful for scientists working in this field. Each team in the drug discovery and development group will find some useful information in this book. There are many books in this area, but this one appears to discuss the topics in a bit greater detail.- Rahmat M. Talukder, PhD, RPh (The University of Texas at Tyler