Del i serien Methods & Principles in Medicinal Chemistry

Drug Development Approaches for Poorly Soluble Compounds

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Inbunden, Engelska, 2026

2 189 kr

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Ten proven strategies to overcome solubility challenges in drug development Poor water solubility prevents drug candidates from reaching their therapeutic targets, causing promising compounds to fail during development. Drug Development Approaches for Poorly Soluble Compounds presents ten distinct strategies for overcoming this challenge, from altering drug structure and creating prodrugs to formulation techniques using nanosuspensions, microemulsions, micelles, co-crystals, and co-solvents. Each approach includes case studies from current pharmaceutical industry projects. This reference covers strategies applicable to virtually every drug type, regardless of molecular size or chemical composition. Beyond formulation science, the book addresses solubility-related commercial and regulatory considerations essential for bringing drugs to market. Special attention is given to animal study requirements for poorly soluble compounds. Each chapter demonstrates approaches through examples from recent pharmaceutical development projects across small and large companies. Readers will also find: Detailed explanations of ten formulation strategies including nanosuspensions, microemulsions, micelles, co-crystals, and co-solvent approaches for enhancing drug solubilityPractical case studies drawn from recent pharmaceutical industry drug development projects demonstrating real-world applications of each solubility enhancement strategyGuidance on regulatory considerations specific to poorly soluble compounds, helping developers navigate approval pathways more efficiently throughout the development processCoverage of special requirements for conducting animal studies with compounds that exhibit poor solubility in biological fluidsCommercial considerations for solubility enhancement strategies that reduce required drug substance amounts, lowering costs and minimizing potential side effectsDesigned for medicinal chemists, pharmaceutical chemists, pharmacologists, and pharmaceutical industry professionals, this book ensures no drug candidate fails due to solubility challenges. The strategies presented here apply across compound types and development stages, providing practitioners with proven solutions for this common development obstacle.

Produktinformation

Utgivningsdatum2026-07-15
Mått170 x 244 x undefined mm
FormatInbunden
SpråkEngelska
SerieMethods & Principles in Medicinal Chemistry
Antal sidor464
FörlagWiley-VCH Verlag GmbH
ISBN9783527354788

Tillhör följande kategorier

Farmakologi inom Medicin
Organisk kemi inom Naturvetenskap och teknik

Dr. Yogeshwar Bachhav, is a distinguished pharmaceutical professional with over 19 years of experience in drug development, spanning R&D, CMC, regulatory strategy, and business development. From his previous experiences working at Pantec Biosolutions AG (Licheteinstein), DebioPharm (Switzerland), AiCuris (Germany) and as a founder and Director of Adex Pharma, to date he has successfully contributed to the CMC development of several drug candidates from discovery to clinical and commercial phases. Currently, he also serves as an Independent Consultant at AiCuris Anti-infective Cures AG, Germany, leading formulation design, outsourcing, and regulatory documentation (IMPD/IND, ANDA) across global markets. Dr. Bachhav holds M.Pharm in Pharmaceutical Chemistry and PhD in Pharmaceutics and from ICT (Mumbai), an LL.B from the University of Mumbai, and a Global MBA from the University of Western Australia, along with an Advanced Business Management certification from IIM Kozhikode. With 19 peer-reviewed publications, 7 international patents, more than 50 invited talks globally and as an editor of 3 books , Dr Bachhav continues to advance pharmaceutical innovation through his deep scientific expertise and strategic leadership. Helmut Buschmann Jörg Holenz Christa Müller

1. Drug development approaches for poorly soluble compounds 2. Solid dispersion technique to improve solubility and, thereby, bioavailability 3. Nanosizing of drugs to improve the apparent dissolution and bioavailability 4. Pharmaceutical Co-crystals 5. Self-micro emulsifying and self-emulsifying drug delivery systems to improve solubility and bioavailability 6. Liposomes and mixed micelles for improvement of drug solubility 7. Improvement of solubility and bioavailability of poorly soluble drugs using mesoporous silica particles8. Gastrointestinal Dissolution and Absorption of BCS Class II Drugs 9. Cyclodextrin-Based Formulations to Improve Solubility of poorly soluble drugs 10. Cosolvent-based formulations to improve solubility and bioavailability11. First in-animal studies and formulation considerations 12. Improving aqueous solubility of drug candidates through structural modifications1. Drug development approaches for poorly soluble compounds 2. Solid dispersion technique to improve solubility and, thereby, bioavailability 3. Nanosizing of drugs to improve the apparent dissolution and bioavailability 4. Pharmaceutical Co-crystals 5. Self-micro emulsifying and self-emulsifying drug delivery systems to improve solubility and bioavailability 6. Liposomes and mixed micelles for improvement of drug solubility 7. Improvement of solubility and bioavailability of poorly soluble drugs using mesoporous silica particles8. Gastrointestinal Dissolution and Absorption of BCS Class II Drugs 9. Cyclodextrin-Based Formulations to Improve Solubility of poorly soluble drugs 10. Cosolvent-based formulations to improve solubility and bioavailability11. First in-animal studies and formulation considerations 12. Improving aqueous solubility of drug candidates through structural modifications