Drug Design

Methodology, Concepts, and Mode-of-Action

Inbunden, Engelska, 2013

Av Gerhard Klebe

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Unique work on structure-based drug design, covering multiple aspects of drug discovery and development.

Produktinformation

Utgivningsdatum2013-07-10
Mått155 x 235 x 54 mm
Vikt1 540 g
FormatInbunden
SpråkEngelska
Antal sidor901
Upplaga2013
FörlagSpringer-Verlag Berlin and Heidelberg GmbH & Co. KG
ISBN9783642179068
OriginaltitelWirkstoffdesign

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Apotek och farmaceuter inom Medicin
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Tillverkningsteknik inom Naturvetenskap och teknik
Medicinsk utrustning och medicinska tekniker inom Medicin
Farmakologi inom Medicin

Part I Fundamentalsin Drug Research.- 1. Drug Research Yesterday, Today and Tomorrow.- 2. The Role of Serendipityin Drug Research.- 3. Classical Drug Research.- 4. Protein–Ligand Interactionsas the Basis for Drug Action.- 5. Optical Activity and Biological Effects.- Part II Discovery and Optimizationof Lead Compounds.- 6. Screeningfor Lead Structures.- 7. Screening Technologies for LeadDiscovery.- 8. Optimizationof Lead Structures.- 9. Designingprodrugs.- 10. Peptidomimetics.- Part III Experimental and Theoretical Methods.- 11. Combinatorics: Chemistry With Big Numbers.- 12. Gene Technology in drug research.- 13. Experimental Methods of Structure Determination.- 14. The Spatial Structure of Biomolecules.- 15. Molecular Modelling.- 16. Conformational Analysis.- Part IV Structure–Activity Relationships and Design Approaches.- 17.Pharmacophore Hypothesis and Molecular Comparisons.- 18. Quantitative Structure–ActivityRelationships.- 19. From in vitro to in vivo:Optimization of ADME-Tox Properties.- 20. ProteinModeling and Structure-BasedDrug Design.- 21. ACase Study: Structure-Based Inhibtor Design for tRNA-Guanine Transglycosylase.- Part V. Drugs and drug action: Successes of stucture-based design.- 22. Howdrugs act: Concepts for therapy.- 23. Inhibitors of hydrolases With an acyl-enzymeintermediate.- 24. Asparticprotease inhibitors.- 25. Inhibitorsof hydrolysing metalloenzymes.- 26. Inhibitorsof transferases.- 27. Inhibitors ofoxidoreductases.- 28. Agonists and antagonistsof nuclear receptors.- 29. Agonists and antagonists of membrane-bound.- 30. Ligands forchannels, pores and transporters.- 31. Ligands for surfacereceptors.- 32. Biologicals: Peptides, proteins, nucleotidesand macrolides as drugs.

Aus den Rezensionen: "... stellt eine sehr gute Informationsquelle fur einen Diplomanden oder Doktoranden der pharmazeutischen Chemie dar, der in diesem Bereich arbeitet und am Beginn seiner wissenschaftlichen Karriere steht ... fur jeden Lehrenden in der pharmazeutischen Chemie geeignet, um die Vorlesung um interessante Aspekte zu erganzen." (Dr. Stefan Fischer, in: MMP Medizinische Monatsschrift fur Pharmazeuten, Heft 6, 2014)