Drinking Water and Health, Volume 9

Safe Drinking Water Committee, National Research Council

• 1 Front Matter; 2 Part I: DNA Adducts; 3 Executive Summary; 4 1 Biologic Significance of DNA Adducts and Protein Adducts; 5 2 DNA-Adduct Technology; 6 3 Conclusions and Recommendations; 7 Appendix A: Drinking Water Contaminant Candidates for Development of Baseline Data on Formation of DNA Adducts; 8 Glossary; 9 Biographical Sketches; 10 Part II: Mixtures; 11 Executive Summary; 12 1 Introduction; 13 2 Pharmacokinetics and the Risk Assessment of Drinking Water Contaminants; 14 3 Risk Assessment of Mixtures of Systemic Toxicants in Drinking Water; 15 4 Assessment of Exposure to Organophosphorus Conpounds, Carbamates, and Volatile Organic Chemicals; 16 5 Acetylcholinesterase Inhibitors: Case Study of Mixtures of Contaminates with Similar Biologic Effects; 17 6 Volatile Organic Compounds (VOCs): Risk Assessment of Mixtures of Potentially Carcinogenic Chemicals; 18 7 Conclusions and Recommendations for Research; 19 Appendix A: An Approach for Risk Assessment of Volatile Organic Chemicals in Drinking Water That Uses Experimental Inhalation Data and a Physiologically Based Pharmacokinetic Model; 20 Appendix B: A Model Illustrating Synergism; 21 Appendix C: Models of Response: Dose Additivity and Response Additivity; 22 Biographical Sketches; 23 Part III: Cumulative Index; 24 Index

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