Dose-Response Analysis Using R

Christian Ritz is an Associate Professor at the University of Copenhagen, Denmark.Signe M. Jensen is an Assistant Professor at the University of Copenhagen, Denmark.Daniel Gerhard is a Senior Lecturer at the University of Caterbury, New Zealand.Jens Carl Streibig is Professor Emeritus at the University of Copenhagen, Denmark.

• IntroductionDose-response modelsEstimation proceduresModel selection and model averagingModel diagnostics and how to fix violationsInverse regressionSimultaneous inferenceGrouped dataNonlinear mixed effects modelsDesign of experimentsAppendix

"Dose-response modelling is an important topic in several disciplines ranging from chemistry, biology, (eco)toxicology to medicine. The statistical programming language R currently provides the most advanced dose response modelling framework, yet a comprehensive resource that gives guidance on implementation is missing. This book fills this void and with its accessible style and brevity is likely to become the standard authority resource for dose response modelling in R. The book is structured along dose response models for different types of responses (e.g. continuous, counts) and also contains chapters on more advanced topics such as hierarchical models. It takes an example-based approach, allowing the reader to reproduce every step of the analysis for selected case studies. Importantly, this empowers readers to apply the models to their own problems and helps with interpretation. Overall, the book is a valuable resource for both individuals new to dose response modelling and as a reference for individuals already familiar with the models and concepts, who want to fit dose response models in R. If you want a book that provides you with the R code and interpretation of simple and complex dose response models, this is the book for you!" - Ralf Schafer, University Koblenz-Landau"Analysis of dose-response curves is one of the critical ways used to assess the effect of a toxicant (or other treatments) on plant growth. I have done many such analyses using the drc module in R developed by the authors of Dose-Response Analysis Using R. This new book is a wonderful new compendium of methodologies illustrated with relevant examples to conduct such analyses properly. A ‘Must Have’ resource for anyone relying on dose-response analysis in their work."—Franck E. Dayan, Agricultural Biology Department, Colorado State University"This book will be useful to both applied statisticians and a wide range of biologists. It combines a text on statistical modeling of dose-response data with lots of examples of using R and the drc package for data analysis. Appendix B, describing models for dose-response data, is an extremely useful and thorough overview of the huge number of possible models. It contains cross-references between equivalent models and a wealth of literature citations from diverse fields. This alone is worth the price of the book. The examples are drawn from the published literature. They provide a nice range of complexity, starting with simple introductions and finishing with quite complex analyses." - Philip Dixon, Iowa State University