Takashi Daimon, Department of Biostatistics, Hyogo College of MedicineAkihiro Hirakawa, Center for Advanced Medicine and Clinical Research, Nagoya University Graduate School of MedicineShigeyuki Matsui, Department of Biostatistics, Nagoya University Graduate School of Medicine

• 1. Introduction.- 2. Dose Finding in Early Phase Clinical Trials.- 3. Rule.- Based Designs.- 4. Continual Reassessment Method Designs.- 5. Escalation with Overdose Control Designs.- 6. Decision.- Theoretic Designs.- 7. Complex Designs.

“The book under review is intended to serve as a brief handbook for graduate students and biostatistics, as well as for oncologists who are involved in the analysis of methods for developing optimal doses for treating cancer in the early stages.” (Fatima T. Adylova, zbMATH 1427.92001, 2020)

Takashi Daimon, Department of Biostatistics, Hyogo College of MedicineAkihiro Hirakawa, Center for Advanced Medicine and Clinical Research, Nagoya University Graduate School of MedicineShigeyuki Matsui, Department of Biostatistics, Nagoya University Graduate School of Medicine

• 1. Introduction.- 2. Dose Finding in Early Phase Clinical Trials.- 3. Rule.- Based Designs.- 4. Continual Reassessment Method Designs.- 5. Escalation with Overdose Control Designs.- 6. Decision.- Theoretic Designs.- 7. Complex Designs.

“The book under review is intended to serve as a brief handbook for graduate students and biostatistics, as well as for oncologists who are involved in the analysis of methods for developing optimal doses for treating cancer in the early stages.” (Fatima T. Adylova, zbMATH 1427.92001, 2020)

Takashi Daimon, Department of Biostatistics, Hyogo College of MedicineAkihiro Hirakawa, Center for Advanced Medicine and Clinical Research, Nagoya University Graduate School of MedicineShigeyuki Matsui, Department of Biostatistics, Nagoya University Graduate School of Medicine

• 1. Introduction.- 2. Dose Finding in Early Phase Clinical Trials.- 3. Rule.- Based Designs.- 4. Continual Reassessment Method Designs.- 5. Escalation with Overdose Control Designs.- 6. Decision.- Theoretic Designs.- 7. Complex Designs.

“The book under review is intended to serve as a brief handbook for graduate students and biostatistics, as well as for oncologists who are involved in the analysis of methods for developing optimal doses for treating cancer in the early stages.” (Fatima T. Adylova, zbMATH 1427.92001, 2020)